Cepralock 2.6 g Intramammary Suspension for Cattle.
Indications for use:
Prevention of ascending intramammary infections throughout the dry period.
In cows considered likely to be free of sub-clinical mastitis, the product may be suitable for use on its own in dry cow management for mastitis control.
Selection of cows for treatment with the product should be based on veterinary clinical judgement. Selection criteria may be based on the mastitis and cell count history of individual cows, or recognised tests for the detection of sub-clinical mastitis or bacteriological sampling.
Do not use the product alone in cows with clinical or sub-clinical mastitis at drying off period. See section “Special precautions for use”.
Do not use during lactation.
Special warnings for each target species:
In clinical field trials, use of the product was combined with a long-acting intramammary antimicrobial at drying-off.
Special precautions for use:
It is good practice to observe dry cows regularly for signs of clinical mastitis. If a sealed quarter develops clinical mastitis, the affected quarter should be stripped out manually before appropriate therapy is instituted.
To reduce the risk of contamination, do not immerse the syringe in water.
Use the syringe only once.
It is important to observe strict aseptic technique for the administration of the product, because the product does not have antimicrobial activity.
Do not administer any other intramammary product following administration of the product.
In cows that may have sub-clinical mastitis, the product may be used following administration of a suitable dry cow antibiotic treatment to the infected quarter.
Avoid contact with skin or eyes.
Should skin or eye contact occur, wash the affected area thoroughly with water.
If irritation persists, seek medical advice and show this label to the doctor.
If you know that you are allergic to bismuth salts, avoid using this product.
Wash hands after use.
Use during pregnancy, lactation or lay:
As the product is not systemically absorbed following intramammary infusion, the product can be used in pregnant animals. At calving, the seal may be ingested by the calf. Ingestion of the product by the calf is safe and produces no adverse effects.
If accidentally used in a lactating cow, a transient rise in somatic cell count (up to 2-fold) may be observed. In such an event, strip out the seal manually, no additional precautions are necessary.
In clinical trials, the compatibility of the product has only been shown with a cloxacillin-containing dry cow preparation.
Amounts to be administered and administration route:
Infuse the content of one syringe of the product into each udder quarter immediately after the last milking of the lactation (at drying off). Do not massage the teat or udder after infusion of the product.
Care must be taken not to introduce pathogens into the teat in order to reduce the risk of post-infusion mastitis (aseptic technique).
It is essential that the teat is thoroughly cleaned and disinfected, with surgical spirit or alcohol-impregnated wipes. The teats should be wiped until the wipes are no longer visibly dirty. Teats should be allowed to dry prior to infusion. Infuse aseptically and avoid contamination of the syringe nozzle. Following infusion it is advisable to use an appropriate teat dip or spray.
Under cold conditions the product may be warmed to room temperature in a warm environment to aid syringeability.
Twice the recommended dose has been administered to cows without any clinical adverse effects.
Meat & offal: zero days.
Milk: zero hours.
Shelf-life of the veterinary medicinal product as packaged for sale: 3 years.
Special precautions for storage:
No special precautions for storage.
Low density polyethylene syringe with a smooth tapered hermetically sealed nozzle.
Cartons of 24 and 60 syringes or buckets of 120 syringes including 24, 60 or 120 individually wrapped teat cleaning towels.
Not all pack sizes may be marketed.
Any unused veterinary medicinal product or waste materials derived from such veterinary medicinal product should be disposed of in accordance with local requirements.
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