Carprodolor 50 mg/ml solution for injection 50ml

Carprodolor 50 mg/ml solution for injection 50ml

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Item Number: CARPRODIN 
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Unit Price:

£52.39 (Incl. Vat)

Usually despatched within 24-48 hours


NB This is a prescription only medicine
How do I buy Prescription medicines from you?

  1. Obtain a Prescription from your vet
  2. Place your order online or by phone
  3. Either fax email* or post your prescription to us.
  4. “Controlled Drugs” can only be dispensed ofter receipt of an original valid prescription sent by post. Controlled Drugs must be sent via tracked, signature delivery and do not qualify for free delivery.
  5. **Unless your vet has stated that the original must be sent to us.
  6. Choose your delivery method. Either Royal Mail Special Delivery which operates a next working day service, requiring a signature(Our recommended option). Or First class post which is free, but at your own risk, and is usually next working day but may take longer.
  7. Hyperdrug Pharmaceuticals Ltd, Middleton In Teesdale, Barnard Castle, County Durham, DL12 0NG.

You are ordering items which require a prescription, Tampering with a prescription or attempting to obtain extra unauthorise supplies is a criminal offence and will have to be reported to the authorities. “Controlled Drugs” can be only be dispensed ofter receipt of an original valid prescription sent by post. Controlled Drugs are sent via tracked, signature delivery.

  1. Place your order online or by phone
  2. Obtain a Prescription from your vet
  3. Either post the original, fax it to 01833 641032, or email it to us at [email protected]

 I have a prescription on file
 I am sending you a prescription by email
 I am sending you a prescription by fax
 I am sending you a prescription by post


Carprodolor 50 mg/ml solution for injection 50ml.

Target species

Indications for use,specifying the target species
The product is indicated as an adjunct to antimicrobial therapy to reduce clinical signs in acute infectious respiratory disease and acute mastitis in cattle.

Do not use in animals suffering from cardiac, hepatic or renal impairment.
Do not use in animals suffering from gastro-intestinal ulceration  or bleeding.
Do not use where there is evidence of a blood dyscrasia.
Do not use in cases of hypersensitivity to the active substance or to any of the excipients.

Special warnings

Special precautions for use
i. Special precautions for use in animals

Avoid use in any dehydrated, hypovolaemic or hypotensive animal, as there is a potential risk of increased renal toxicity. Concurrent administration of potentially nephrotoxic drugs should be avoided.

Do not exceed the stated dose or the duration of treatment.

Do not administer other NSAID's concurrently or within 24 hours of each other.

As NSAID therapy can be accompanied by GI or renal impairment, adjunctive fluid therapy should be considered especially in the case of acute mastitis treatment.

ii. Special precautions to be taken by the person administering the veterinary medicinal product to animals

Carprofen, in common with other NSAIDs, has been shown to exhibit photosensitising potential in laboratory studies.  Avoid skin contact with the veterinary medicinal product. Should this occur, wash the affected areas immediately.

Take care to avoid accidental self-injection.  In the event of accidental self-injection seek medical advice immediately.

Adverse reactions (frequency and seriousness)
Studies in cattle have shown that a transient local reaction may form at the site of the injection.

Use during pregnancy, lactation or lay
In the absence of any specific studies in pregnant cattle, use only after a risk/benefit assessment has been performed by the attending veterinary surgeon.

Interaction with other medicinal products and other forms of interaction
No specific significant drug interactions have been reported for carprofen. During clinical studies in cattle four different antibiotic classes were used, macrolides, tetracyclines, cephalosporins and potentiated penicllins without known interactions.   However, in common with other NSAIDs, carprofen should not be administered simultaneously with another veterinary medicinal product of the NSAID or glucocorticoid class.  Animals should be carefully monitored if carprofen is administered simultaneously with an anticoagulant.

NSAID's are highly bound to plasma proteins and may compete with other highly bound drugs, such that concomitant administration may result in toxic effects.

Amounts to be administered and administration route
Single subcutaneous or intravenous injection at a dosage of 1.4 mg carprofen/ kg body weight (1 ml/35 kg) in combination with antibiotic therapy, as appropriate.

The stopper should not be punctured more than 20 times.

Overdose (symptoms, emergency procedures, antidotes), if necessary
In clinical studies, no adverse signs were reported after intravenous and subcutaneous administration of up to 5 times the recommended dose. 

There is no specific antidote for carprofen overdosage but general supportive therapy, as applied to clinical overdosage with NSAID's, should be applied.

Withdrawal period(s)
Meat and offal: 21 days
Milk:    Zero hours

Pharmacotherapeutic group: Anti-inflammatory and Anti-rheumatic products, non-steroids
ATCvet code:  QM01AE91

Pharmacodynamic properties
Carprofen is a member of the 2-arylpropionic acid group of non-steroidal anti-inflammatory drugs (NSAID's), and possesses anti-inflammatory, analgesic and antipyretic activity. 

Carprofen, like most other NSAID's is an inhibitor of the enzyme cyclo-oxygenase of the arachidonic acid cascade. However, the inhibition of prostaglandin synthesis by carprofen is slight in relation to its anti-inflammatory and analgesic potency. The precise mode of action is unclear.

Studies have shown that carprofen has potent antipyretic activity and significantly reduces the inflammatory response in lung tissue in cases of acute, pyrexic infectious respiratory disease in cattle. Studies in cattle with experimentally induced acute mastitis have shown that carprofen administered intravenously has potent antipyretic activity and improves heart rate and rumen function.

Pharmacokinetic particulars
Absorption: Following a single subcutaneous dose of 1.4 mg carprofen/kg the maximum plasma concentration (Cmax) of 15.4 ?g/ml was reached after (Tmax) 7-19 hours.

Distribution: The highest carprofen concentrations are found in bile and plasma and more than 98% of carprofen is bound to plasma proteins. Carprofen was well distributed in the tissues with the highest concentrations found in kidney and liver followed by fat and muscle.

Metabolism: Carprofen (parent) is the main component in all tissues. Carprofen (parent compound) is slowly metabolised primarily by ring hydroxylation, hydroxylation at the ?-carbon and by conjugation of the carboxylic acid group with glucuronic acid. The 8-hydroxylated metabolite and unmetabolized carprofen predominate in the faeces. Bile samples are comprised of conjugated carprofen.

Elimination: Carprofen has a plasma elimination half-life of 70 hours. Carprofen is primarily excreted in the faeces, indicating that the biliary secretion plays an important role.

List of excipients
Ethanol 96%
Macrogol 400
Poloxamer 188
Water for injection

In the absence of compatibility studies, this veterinary medicinal product must not be mixed with other veterinary medicinal products.

Shelf life
Shelf-life of the veterinary medicinal product as packaged for sale: 3 years
Shelf-life after first opening the immediate packaging: 28 days

Special precautions for storage
Do not refrigerate or freeze
Keep the vial in the outer carton in order to protect from light.

Nature and composition of immediate packaging
50 ml amber glass (Type I) vials capped with chlorbutyl rubber stopper retained by an aluminium crimped seal in a cardboard box.

Special precautions for the disposal of unused veterinary medicinal product or waste materials derived from the use of such products
Any unused veterinary medicinal product or waste materials derived from such veterinary medicinal products should be disposed of in accordance with local requirements


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