Carprieve 5%w/v Small Animal Solution for Injection 20ml

Carprieve 5%w/v Small Animal Solution for Injection 20ml


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Item Number: CARPRIISA 
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Unit Price:

£44.59 (Incl. Vat)

Usually despatched within 24 hours

Quantity

NB This is a prescription only medicine
How do I buy Prescription medicines from you?

  1. Obtain a Prescription from your vet
  2. Place your order online or by phone
  3. Either fax email* or post your prescription to us.
  4. “Controlled Drugs” such as Epiphen or Tramadol can be only be dispensed ofter receipt of an original valid prescription sent by post. Controlled Drugs must be sent via tracked, signature delivery and do not qualify for free delivery.
  5. **Unless your vet has stated that the original must be sent to us.
  6. Choose your delivery method. Either Royal Mail Special Delivery which operates a next working day service, requiring a signature(Our recommended option). Or First class post which is free, but at your own risk, and is usually next working day but may take longer.
  7. Hyperdrug Pharmaceuticals Ltd, Middleton In Teesdale, Barnard Castle, County Durham, DL12 0NG.
X

You are ordering items which require a prescription, Tampering with a prescription or attempting to obtain extra unauthorise supplies is a criminal offence and will have to be reported to the authorities. “Controlled Drugs” such as Epiphen or Tramadol can be only be dispensed ofter receipt of an original valid prescription sent by post. Controlled Drugs are sent via tracked, signature delivery.

  1. Place your order online or by phone
  2. Obtain a Prescription from your vet
  3. Either post the original, fax it to 01833 641032, or email it to us at [email protected]

 I have a prescription on file
 I am sending you a prescription by email
 I am sending you a prescription by fax
 I am sending you a prescription by post



Description

Carprieve 5%w/v Small Animal Solution for Injection 20ml.

Target species
Dogs and Cats
 
Indications for use, specifying the target species
In the dog it is indicated for the control of post-operative pain and inflammation following orthopaedic and soft tissue (including intra-ocular) surgery. In the cat it is indicated for the treatment of post operative pain following surgery.

Contraindications
Do not administer by intramuscular injection.
Do not exceed the recommended dose or duration of treatment.
Do not administer NSAIDs concurrently or within 24 hours of each other.  Some NSAIDs may be highly bound to plasma proteins and compete with other highly bound drugs, which can lead to toxic effects.
Do not use in animals suffering from cardiac, hepatic or renal disease, where there is a possibility of gastrointestinal ulceration or bleeding, or hypersensitivity to the product.  As with other NSAIDs there is a risk of rare renal or idiosyncratic hepatic adverse events.

In the absence of any specific studies in pregnant target animals such use is not indicated. 

Special Warnings for each target species
Do not use in animals suffering from cardiac, hepatic or renal disease, where there is a possibility of gastrointestinal ulceration or bleeding, or hypersensitivity to the product.  As with other NSAIDs there is a risk of rare renal or idiosyncratic hepatic adverse events.
 
Special precautions for use
(i) Special precautions for use in animals

Do not use in cats less than 5 months of age.  Use in dogs less than 6 weeks of age, or in aged dogs and cats, may involve additional risk.  If such use cannot be avoided, such animals may require a reduced dosage and careful clinical management.

Avoid use in any dehydrated, hypovolaemic or hypotensive animal, as there is a potential risk of increased renal toxicity.

Concurrent administration of potential nephrotoxic drugs should be avoided.

NSAIDs can cause inhibition of phagocytosis and hence in the treatment of inflammatory conditions associated with bacterial infection, appropriate concurrent antimicrobial therapy should be instigated.

(ii) Special precautions to be taken by the person administering the veterinary medicinal product to animals

Care should be taken when handling the product to avoid accidental self-injection and skin contact.  If skin contact occurs wash any product from the skin immediately. Wash hands after use.

Adverse reactions (frequency and seriousness)
None Known.

Use during pregnancy, lactation or lay
In the absence of any specific studies in pregnant target animals such use is not indicated. 
 
Interaction with other medicinal products and other forms of interaction
Do not administer NSAIDs concurrently or within 24 hours of each other.  Some NSAIDs may be highly bound to plasma proteins and compete with other highly bound drugs, which can lead to toxic effects.

Concurrent administration of potential nephrotoxic drugs should be  avoided.

Amounts to be administered and administration route
In the dog, the recommended dosage is 4mg/kg (1ml/12.5kg) bodyweight, by intravenous or subcutaneous injection, best given pre-operatively, either at the time of premedication or induction of anaesthesia.

Clinical trial evidence in dogs suggests that only a single dose of carprofen is required in the first 24 hours peri-operatively; if further analgesia is required within this period, a single half-dose (2mg/kg) of carprofen may be given to dogs as necessary.

In the cat, the recommended dosage is 4mg/kg (0.24ml/3kg) bodyweight as a single dose by subcutaneous or intravenous injection, best given pre-operatively at the time of anaesthesia.  In the cat, due to the longer half-life, and narrower therapeutic index, particular care should be taken not to exceed the recommended dose and the use of a 1ml graduated syringe is recommended to measure the dose accurately.

Overdose (symptoms, emergency procedures, antidotes), if necessary

Carprofen is well tolerated up to 3 times the recommended dose for dogs and up to twice the recommended dose for cats.

There is no specific antidote for carprofen overdosage but general supportive therapy as applied to clinical overdosage with NSAIDs should be applied.

Withdrawal period
Not applicable

PHARMACOLOGICAL PROPERTIES
Pharmacotherapeutic group: Antinflammatory & antirheumatic products-  
Non -steroids.

ATC Vet Code:  QM01AE91

Pharmacodynamic properties
Carprofen (CPF), ( )-6-chloro- -methylcarbazole-2-acetic acid, is a nonsteroidal anti-inflammatory drug (NSAID) with analgesic and anti-pyretic properties.  It is a derivative of phenylpropionic acid and a member of the arylpropionic acid class of NSAIDs.  As a representative of the 2-arylpropionic family, it contains a chiral center at C2 of the propionic moiety and therefore, exists in 2 sterioisomeric forms, the (+)-S and (-)-R enantiomers. 

The mechanism of action of carprofen is unclear, there are two principal theories.  One proposes that carprofen is a selective inhibitor of the cyclo-oxygenase isoenzyme, COX-2.  The second hypothesis that carprofen is a weak inhibitor of both cyclo-oxygenase isoforms, COX-1 and COX-2, and that it acts, at least partially, by some other unknown mechanism.

Pharmacokinetic properties
Absorption of carprofen is reported to be rapid and complete in the dog. The volume of distribution is small with the highest drug concentrations observed in plasma, which has been ascribed to a high degree of binding to plasma protein.  In the cat, following intravenous or subcutaneous administration, the clearance and volume of distribution were greater and elimination half-life was shorter for S(+) carprofen.  Bioavailability after subcutaneous dosing was complete.
 
PHARMACEUTICAL PARTICULARS
List of excipients
Benzyl Alcohol,
Sodium Formaldehyde Sulphoxylate
L-Arginine,
Lutrol F68,
Water for Injection.

Incompatibilities
None known.

Shelf life
Shelf life of the veterinary medicinal product as packeged for sale: 2 Years

Shelf life after opening the immediate packaging: 28 days.
 
Special precautions for storage
Do not store above 25°C.
 Protect from light.
 Following withdrawal of the first dose, use the product with 28 days.

Nature and composition of immediate packaging
Carton containing 1 x 20 ml multidose amber glass (type 1) vial with 20 mm bromobutyl bungs and 20 mm aluminium seals.

Special precautions for the disposal of unused veterinary medicinal product or waste materials derived from the use of such products
Any unused product or waste material should be disposed of in accordance with national requirements.

Delivery

Free shipping from Hyperdrug

Value Weight Delivery Charge*  
Over £49.00 Any Weight FREE*
Under £49.00 Under 250g £2.49
Under £49.00 No weight limit £4.99

Most orders are despatched the same day and standard delivery is 3 to 5 working days from despatch. FAST Expedited delivery options are available.

Estimated " Usually shipped in" information is shown against most products

 

Due to the large volume of parcels Royal Mail and Parcel Force handle over the Christmas period, we advise you give as much time as possible to receive your goods. Please ensure you order any essentials, such as prescription only medicines and diets, as soon as possible for UK delivery before Christmas. 
 
Last posting dates to expect goods before Christmas
Royal Mail - Wednesday 14th December
Parcel Force - Friday 16th December
Fast Track - Wednesday 21st December
 
Hyperdrug.co.uk website is open 24 hours a day, 7 days a week.
 
Office Opening hours 
Monday 19th - Friday 23rd - OPEN 8am - 5.30pm
Saturday 24th - Tuesday 27th - CLOSED
Wednesday 28th - Friday 30th - OPEN 8am - 5.30pm
Saturday 31st - Monday 2nd - CLOSED
Tuesday 3rd - Friday 6th - OPEN 8am - 5.30pm
Saturday 7th - OPEN 9am - 4pm

Overseas orders

Postage outside of the UK is from £4.95

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