Bilovet 200mg/ml Solution for Injection for cattle & pigs 100ml.
Bilovet is indicated for the treatment of diseases caused by microorganisms, susceptible to tylosin.
Solution for Injection.
Clear, yellow aqueous solution.
Target species: Cattle and pigs.
Indications for use, specifying the target species:
Infections caused by microorganisms susceptible to tylosin.
- Treatment of respiratory infections, metritis caused by Gram-positive micro-organisms, mastitis caused by Streptococcus spp., Staphylococcus spp., or Mycoplasma and interdigital necrobacillosis, caused by Fusobacterium necrophorum , i.e. panaritum or foot rot.
- Treatment of respiratory infections and necrobacillosis (calf diphtheria cause by Fusobacterium necrophorum).
- Treatment of enzootic pneumonia caused by Mycoplasma hyopneumoniae,, haemorrhagic enteritis, (Porcine proliferative haemorrhagic enteropathy due to Lawsonia intracellularis) erysipelas caused by Erysipelothrix rhusiopathiae and metritis.
- Treatment of arthritis caused by Mycoplasma and Staphylococcus spp.
The product should not be given to chickens or turkeys.
Do not administer to horses or other equines in which injection of tylosin may be fatal.
Do not administer to animals with known hypersensitivity to tylosin, other macrolides or any of the excipients.
Special precautions for use in animals:
Use of the product should be based on susceptibility testing of the bacteria isolated from the animal. If this is not possible, therapy should be based on local epidemiological information.
For administration by the intramuscular route only.
Use different injection sites for repeat injections.
Use of the product deviating from the instructions given in the SPC may increase the prevalence of bacteria resistant to the tylosin and may decrease the effectiveness of treatment with other macrolide antibiotics, due to the potential for cross resistance.
Special precautions to be taken by the person administering the veterinary medicinal product to animals
Care should be taken to avoid accidental self-injection.
If accidental self-injection occurs, seek medical attention immediately.
In the event of accidental skin contact, wash thoroughly with soap and water. In case of accidental eye contact, flush the eyes with plenty of clean, running water.
Wash hands after use.
Tylosin may induce irritation. Macrolides, such as tylosin, may also cause hypersensitivity (allergy) following injection, inhalation, ingestion or contact with skin or eye. Hypersensitivity to tylosin may lead to cross reactions to other macrolides and vice versa. Allergic reactions to these substances may occasionally be serious and therefore direct contact should be avoided.
Do not handle the product if you are allergic to ingredients in the product.
If you develop symptoms following exposure, such as skin rash, you should seek medical advice and show the physician this warning. Swelling of the face, lips and eyes or difficulty in breathing are more serious symptoms and require urgent medical attention.
Adverse reactions (frequency and seriousness):
Possible adverse reactions attributed to the product when used as recommended and their frequency are: In very rare cases the following have been observed;
- swelling/inflammation at the site of injection,
- vulval swelling in cattle,
- oedema of the rectal mucosa, partial anal protrusion ('rosebudding'), erythema and pruritus in pigs.
- Anaphylactic shock and death.
Blemishes may occur at the site of injection and can persist for up to 21 days following administration.
Use during pregnancy, lactation or lay:
No adverse effects to tylosin have been seen in fertility, multi-generation or teratology studies.
Use only in accordance with the benefit/risk assessment by the responsible veterinarian.
Interaction with other medicinal products and other forms of interaction:
Lincosamide and aminoglycoside antibiotics can antagonise the action of tylosin.
Amounts to be administered and administration route:
For intramuscular injection:
Cattle: 5-10 mg tylosin/kg bodyweight per day for 3 days (2.5 to 5 ml solution for injection per 100 kg bodyweight). Maximum injection volume per injection site should not exceed 15 ml.
Pigs: 5-10 mg tylosin/kg bodyweight per day for 3 days (2.5 to 5 ml solution for injection per 100 kg bodyweight). Maximum injection volume per injection site should not exceed 1.3 ml.
To ensure a correct dosage, body weight should be determined as accurately as possible
to avoid underdosing.
The closure should not be pierced more than 30 times.
Overdose (symptoms, emergency procedures, antidotes), if necessary:
Pigs and calves: Intramuscular injection of 30mg/kg bodyweight per day (three times maximum recommended dose) for five days produced no adverse effects.
Pigs: Meat and offal - 9 days
Cattle: Meat and offal- 28 days
Milk - 5 days.
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