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Vexocan suspension is a coccidiosis treatment and prevention of coccidial infections in lambs and calves. White aqueous oral suspension containing diclazuril 0.25% w/v.
Background: in 2005 Janssen Animal Healtho conducted a national coccidiosis survey in conjunction with the National Sheep Association
93% of Uk farms tested had coccidia present.
white aqueous oral suspension containing diclazuril 0.25% w/v.
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Significant changes
New species indication: Now licensed for use in calves.
Presentation
White aqueous oral suspension containing diclazuril 0.25% w/v.
Uses
For the treatment and prevention of coccidial infections in lambs caused in particular, by the more pathogenic Eimeria species E. crandallis and E. ovinoidalis. To aid in the control of coccidiosis in calves caused by Eimeria bovis and Eimeria zuernii. Diclazuril is an anticoccidial of the benzeneacetonitrile group. The pharmacological studies performed in laboratory animals could not demonstrate pharmacological effects, other than the anticoccidial effect.
Dependent on the coccidia species, diclazuril has a coccidiocidal effect on the asexual or sexual stages of the development cycle of the parasite. Treatment with diclazuril causes interruption of the coccidial cycle and eliminates excretion of oocysts for up to 14 days.
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Dosage and administration
Shake well before use. After using draw off cap, re-close container with original cap.
Administration
Vecoxan oral suspension should be administered by mouth with a drenching gun. Appropriately graduated drenching equipment must be used to allow accurate administration of the required dose volume. This is particularly important when administering small volumes.
Dosage
LAMBS
Therapeutic use
1 mg diclazuril per kg body weight or 1 ml Vecoxan per 2.5 kg body weight, as a single administration.
Preventative use
1 mg diclazuril per kg body weight or 1 ml Vecoxan per 2.5 kg body weight at about 4-6 weeks of age at the time that coccidiosis can normally be expected on the farm.
Under conditions of high infection pressure, a second treatment may be indicated about 3 weeks after the first dosing.
CALVES
To aid in the control of coccidiosis
1mg diclazuril per kg body weight or 1 ml Vecoxan per 2.5 kg body weight, administered as a single dose, 14 days after moving into a potentially high risk environment. If a satisfactory response is not observed, then further advice should be sought from your veterinary surgeon and the cause of the condition should be reviewed. It is good practice to ensure the cleanliness of calf housing.
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Contra-indications, warnings, etc
Vecoxan is well tolerated in lambs and calves. The administration to lambs of a dose of diclazuril of up to 60 times the therapeutic dose did not reveal any adverse effects. In calves, no adverse effects were recorded at 5 times the prescribed dose, administered for 3 consecutive days. For oral use in lambs and calves only. It is advocated to treat all lambs of the flock, and all calves in a pen. This will contribute to reduce the infection pressure and assure a better epidemiological control of the coccidiosis infection.
Lambs
On rare occasions, in highly susceptible lambs, e.g. where they have been housed for long periods of time before being turned out onto heavily contaminated pasture, a severe scour has been seen shortly after dosing. In such cases, fluid therapy is essential and the use of a sulphonamide should be considered. It is also important to consider other potential pathogens that may be playing a role, e.g. Cryptosporidia, rotavirus, Giardia and E. coli.
In the event of any stress factors (eg cold weather, other diseases) or high challenge (eg warm wet weather, inability to move lambs from infected pastures after dosing) the timing of the doses may need to be adjusted.
Calves
Clinical coccidiosis generally occurs late in the parasite’s life cycle after most of the damage to the calf’s intestine has already been done. This severely damaged intestine can easily be infected by secondary bacteria and/or other agents. In cases of acute clinical coccidiosis treated with Vecoxan, fluid therapy is essential and the use of an antibiotic should be considered. Symptoms of clinical disease may remain obvious in some calves treated with Vecoxan, even though oocyst excretion is reduced to a very low level, and overall prevalence of diarrhoea is decreased.
Keep out of the reach of children. For animal treatment only.
Withdrawal period
Meat: 0 (zero) days.
Operator warnings
Wash hands after administration of the product.
Disposal
Unused product and containers should be disposed of in accordance with any guidance from an appropriate waste disposal authority.
Pharmaceutical precautions
Do not store above 30°C. Protect from frost.
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Legal category
POM-VPS (previously PML).
Packaging Quantities
1 litre, 2.5 litres, 5 litres polyethylene bottles
Further information
Nil
Marketing authorisation number
Vm 00242/4044.
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