Tribrissen Injection 48% 100ml-Hyperdrug

Presentation The undisturbed product is a cream-coloured amorphous sediment in a clear, pale yellow to brown solution. On agitation, a cream- to brown-coloured aqueous suspension for injection is formed. Each 1.0 ml contains: Trimethoprim Ph. Eur 80 mg; Sulphadiazine Ph. Eur 400 mg. Uses Principal action: The two active ingredients produce a sequential double blockade of bacterial synthesis of folinic acid, giving a level of activity many times greater than that obtained from either drug alone. The in vitro activity covers most common Gram-positive and Gram-negative bacteria including: Actinobacillus spp., Actinomyces bovis, Bordetella spp., Corynebacterium spp., Escherichia coli, Fusobacterium necrophorum, Haemophilus spp., Klebsiella spp., Listeria monocytogenes, Nocardia spp., Pasteurella spp., Proteus spp., Salmonella spp., Staphylococcus spp. and Streptococcus spp. Indications The injection may be used in the treatment of a wide range of diseases and conditions of bacterial origin in cattle, pigs and horses: Respiratory infections of bacterial origin. Urogenital tract infections. Alimentary tract infections. Other infections, such as foul-in-the-foot, severe mastitis, bacterial agalactia of sows, infections of the eye, ear or mouth. It may also be used for antibacterial medication in surgical cases where infection is likely to be present, e.g. with compound fractures and where there is established peritonitis. Dosage and administration Dose For cattle, pigs and horses the dose is 1 ml per 32 kg (70 lb) bodyweight daily, i.e. equivalent to 15 mg active ingredients/kg bodyweight. In cases of severe infection the dose may be increased to 1.5 ml per 32 kg (70 lb) daily i.e. equivalent to 22.5 mg active ingredients/kg bodyweight. A single injection may be sufficient in uncomplicated conditions such as wounds and post operative infections, but in all severe or complicated infections the dose should be repeated daily for up to five days, or until two days after the symptoms resolve, up to a maximum of five consecutive days. Administration Agitate gently before withdrawing each dose, avoiding excessive frothing. By intramuscular injection. It is recommended that in cattle and horses not more than 20 ml, and in pigs not more than 10 ml, be injected at any one site. Contra-indications, warnings, etc Warnings Do not administer by the intravenous or intra-peritoneal route. Very occasionally there may be a temporary swelling at the site of injection. The period of time between the withdrawal of the first and final doses from the container should not exceed 4 weeks. Keep out of reach of children. For animal treatment only. Protection of consumers Not for use in horses intended for human consumption. Animals must not be slaughtered for human consumption during treatment. Cattle may only be slaughtered for human consumption after 34 days from the last treatment. Pigs may only be slaughtered for human consumption after 28 days from the last treatment. Milk for human consumption must not be taken during treatment. Milk for human consumption may be taken from animals only after 6.5 days (156 hours) from the last treatment. Pharmaceutical precautions Do not store above 25°C. Protect from light. Do not freeze. Following withdrawal of the first dose, use the product within 28 days. Discard unused material. Once opened the product should be used within 28 days and any remainder discarded. Disposal Dispose of any unused product and containers in accordance with guidance from your local waste regulation authority, e.g. the local regional office of the Environment Agency or SEPA. Legal category POM-V (previously POM). Packaging Quantities Amber glass bottle of 100 ml Further information Animals may be treated by injection alone, or an initial injection may be followed by daily administration of one of the oral Tribrissen formulations where appropriate. Marketing authorisation number Vm 0201/4108.

Dosage and administration Dose For cattle, pigs and horses the dose is 1 ml per 32 kg (70 lb) bodyweight daily, i.e. equivalent to 15 mg active ingredients/kg bodyweight. In cases of severe infection the dose may be increased to 1.5 ml per 32 kg (70 lb) daily i.e. equivalent to 22.5 mg active ingredients/kg bodyweight. A single injection may be sufficient in uncomplicated conditions such as wounds and post operative infections, but in all severe or complicated infections the dose should be repeated daily for up to five days, or until two days after the symptoms resolve, up to a maximum of five consecutive days. Administration Agitate gently before withdrawing each dose, avoiding excessive frothing. By intramuscular injection. It is recommended that in cattle and horses not more than 20 ml, and in pigs not more than 10 ml, be injected at any one site.

Contra-indications, warnings, etc Warnings Do not administer by the intravenous or intra-peritoneal route. Very occasionally there may be a temporary swelling at the site of injection. The period of time between the withdrawal of the first and final doses from the container should not exceed 4 weeks. Keep out of reach of children. For animal treatment only. Protection of consumers Not for use in horses intended for human consumption. Animals must not be slaughtered for human consumption during treatment. Cattle may only be slaughtered for human consumption after 34 days from the last treatment. Pigs may only be slaughtered for human consumption after 28 days from the last treatment. Milk for human consumption must not be taken during treatment. Milk for human consumption may be taken from animals only after 6.5 days (156 hours) from the last treatment. Pharmaceutical precautions Do not store above 25°C. Protect from light. Do not freeze. Following withdrawal of the first dose, use the product within 28 days. Discard unused material. Once opened the product should be used within 28 days and any remainder discarded. Disposal Dispose of any unused product and containers in accordance with guidance from your local waste regulation authority, e.g. the local regional office of the Environment Agency or SEPA.