Tribrissen Injection 24% 50ml-Hyperdrug

Presentation The undisturbed product is a cream-coloured amorphous sediment in a clear, pale yellow to brown solution. On agitation, a cream- to brown-coloured aqueous suspension for injection is formed. Each 1 ml contains: Trimethoprim Ph.Eur 40 mg; Sulphadiazine Ph.Eur 200 mg. Uses Principal action: The two active ingredients produce a sequential double blockade of bacterial synthesis of folinic acid, giving a level of activity many times greater than that obtained from either ingredient alone. The in vitro activity covers most common Gram-positive and Gram-negative bacteria including: Bordetella spp., Corynebacterium spp., Escherichia coli, Fusobacterium necrophorum, Haemophilus spp., Klebsiella spp., Listeria monocytogenes, Nocardia spp., Pasteurella spp., Proteus spp., Salmonella spp., Staphylococcus spp., Streptococcus spp. Indications The product is recommended for the treatment of bacterial infections in cats and dogs including: Alimentary tract infections. Respiratory tract infections. Urogenital infections. Skin infections and abscesses. Antibacterial medication following surgery where asepsis cannot be guaranteed. Dosage and administration Dose 1 ml per 8 kg bodyweight (equivalent to 30 mg active ingredients/kg bodyweight). Cats and dogs may be treated by injection alone or by an initial injection followed by daily administration of Tribrissen™ 20 or Tribrissen™ 80 tablets. A lower initial dose of 1 ml per 16 kg bodyweight (equivalent to 15 mg active ingredients/kg bodyweight) may be used if it is to be followed by the first Tribrissen tablet within 12 hours. Administration Agitate gently before withdrawing each dose, avoiding excessive frothing. By subcutaneous injection. The recommended site in dogs is the loose skin at the scruff of the neck. A single injection may be sufficient in uncomplicated conditions such as wounds and post-operative infections, but in all severe or complicated infections the dose should be repeated daily for five days or until two days after the symptoms resolve. Contra-indications, warnings, etc Contra-indications Injections should not be given by routes other than those recommended. Do not use on animals with known sulphonamide sensitivity, causing, for example, immune-mediated sterile polyarthritis in dogs; with severe liver parenchymal damage; with blood dyscrasias; with or prone to dry eye; or in cases with severe renal impairment unless the dosage is reduced, adequate urinary output is maintained and close veterinary supervision is available. Warnings A daily dose rate of 120 mg (0.5 ml) per kg bodyweight should not be exceeded and care must be taken in measuring doses for very small animals. Following withdrawal of the first dose, use the product within 28 days. Dispose of any unused product or containers in accordance with guidance from your local waste regulation authority. If cats are treated for more than 5 days, the dose rate should not exceed 30 mg/kg per day. Side-effects Generally, injection of the product is well tolerated. Very occasionally there may be signs of transient pain in dogs and cats or temporary irritation or inflammation at the site of the injection. For animal treatment only. Keep out of reach of children. Pharmaceutical precautions Do not store above 25°C. Protect from light. Do not freeze. Legal category POM-V (previously POM). Packaging Quantities Amber glass bottle of 50 ml. Marketing authorisation number Vm 0201/4065.

Dosage and administration Dose 1 ml per 8 kg bodyweight (equivalent to 30 mg active ingredients/kg bodyweight). Cats and dogs may be treated by injection alone or by an initial injection followed by daily administration of Tribrissen™ 20 or Tribrissen™ 80 tablets. A lower initial dose of 1 ml per 16 kg bodyweight (equivalent to 15 mg active ingredients/kg bodyweight) may be used if it is to be followed by the first Tribrissen tablet within 12 hours. Administration Agitate gently before withdrawing each dose, avoiding excessive frothing. By subcutaneous injection. The recommended site in dogs is the loose skin at the scruff of the neck. A single injection may be sufficient in uncomplicated conditions such as wounds and post-operative infections, but in all severe or complicated infections the dose should be repeated daily for five days or until two days after the symptoms resolve.

Contra-indications, warnings, etc Contra-indications Injections should not be given by routes other than those recommended. Do not use on animals with known sulphonamide sensitivity, causing, for example, immune-mediated sterile polyarthritis in dogs; with severe liver parenchymal damage; with blood dyscrasias; with or prone to dry eye; or in cases with severe renal impairment unless the dosage is reduced, adequate urinary output is maintained and close veterinary supervision is available. Warnings A daily dose rate of 120 mg (0.5 ml) per kg bodyweight should not be exceeded and care must be taken in measuring doses for very small animals. Following withdrawal of the first dose, use the product within 28 days. Dispose of any unused product or containers in accordance with guidance from your local waste regulation authority. If cats are treated for more than 5 days, the dose rate should not exceed 30 mg/kg per day. Side-effects Generally, injection of the product is well tolerated. Very occasionally there may be signs of transient pain in dogs and cats or temporary irritation or inflammation at the site of the injection. For animal treatment only. Keep out of reach of children. Pharmaceutical precautions Do not store above 25°C. Protect from light. Do not freeze.