Synulox Palatable Tablets 50mg-Hyperdrug

Presentation

Synulox Palatable Tablets are presented as circular, pink tablets with a break line on one face and `SYNULOX' engraved on the other. Each tablet contains clavulanic acid as potassium clavulanate and amoxicillin as Amoxicillin trihydrate in a palatable base. The composition of the two tablet sizes is as follows:

50 mg

40 mg amoxicillin and 10 mg clavulanic acid.

250 mg

200 mg amoxicillin and 50 mg clavulanic acid.
Uses

Synulox Palatable Tablets have a notably broad spectrum of bactericidal activity against bacteria commonly found in cats and dogs.

In vitro Synulox is active against a wide range of clinically important aerobic and anaerobic bacteria including:

Gram-positive:
Staphylococci (including ß-lactamase producing strains); Clostridia; Corynebacteria; Peptostreptococcus spp; Streptococci.

Gram-negative:
Bacteroides spp (including ß-lactamase producing strains); Escherichia coli (including most ß-lactamase producing strains); Salmonellae (including ß-lactamase producing strains); Bordetella bronchiseptica; Campylobacter spp; Fusobacterium necrophorum; Klebsiellae; Pasteurellae; Proteus spp.

Clinically Synulox has been shown to be effective in treating a wide range of diseases of cats and dogs including: Skin disease (including deep and superficial pyodermas); soft tissue infections (abscesses and anal sacculitis); dental infections (eg gingivitis); urinary tract infections; respiratory disease (involving upper and lower respiratory tract); enteritis.

Contra-indications, warnings, etc

For animal treatment only. Synulox Palatable Tablets should not be given to rabbits, guinea pigs, hamsters or gerbils. Caution is advised in their use in any other very small herbivores.

Operator warning

Penicillins and cephalosporins may cause hypersensitivity (allergy) following injection, inhalation, ingestion or skin contact. Hypersensitivity to penicillins may lead to cross reaction to cephalosporins and vice-versa. Allergic reaction to these substances may occasionally be serious.

Do not handle this product if you know you are sensitised, or if you have been advised not to work with such preparations. Wash hands after use.

Handle this product with great care to avoid exposure, taking all recommended precautions.

If you develop symptoms following exposure such as skin rash, you should seek medical advice and show the doctor this warning. Swelling of the face, lips or eyes or difficulty with breathing are more serious symptoms, and may require urgent medical attention.
Pharmaceutical precautions

Do not store above 25°C. Store in a dry place. Keep out of the reach of children.

Dispose of any unused product and empty containers in accordance with guidance from your local waste regulation authority.
Legal category

POM-V (previously POM)
Packaging Quantities

Both size tablets are packed in foil strips containing 5×2 tablets. 50 mg tablets are supplied in packs of 100 and 500, 250 mg tablets are in packs of 100 and 250.
Further information

Resistance to many antibiotics is caused by beta-lactamase enzymes which destroy the antibiotic before it can act on the bacteria themselves. The clavulanate in Synulox counteracts this defence mechanism by inactivating the beta-lactamases, thus rendering the organisms sensitive to amoxicillin's rapid bactericidal effect, at concentrations readily attainable in the body.

Synulox is effective against Klebsiella infections found in veterinary practice, but it is not indicated for cases involving Pseudomonas species.

Synulox Palatable Tablets are often accepted from the hand, even by sick dogs and cats. Alternatively, the tablets may be crumbled and added to a little food.

Synulox Palatable Tablets can safely be used during pregnancy and lactation.

Synulox Palatable Drops are available as an alternative presentation for treating small individuals.

Presentation Synulox Palatable Tablets are presented as circular, pink tablets with a break line on one face and `SYNULOX' engraved on the other. Each tablet contains clavulanic acid as potassium clavulanate and amoxicillin as Amoxicillin trihydrate PhEur in a palatable base. The composition of the two tablet sizes is as follows: 50 mg 40 mg amoxicillin and 10 mg clavulanic acid. 250 mg 200 mg amoxicillin and 50 mg clavulanic acid. Uses Synulox Palatable Tablets have a notably broad spectrum of bactericidal activity against bacteria commonly found in cats and dogs. In vitro Synulox is active against a wide range of clinically important aerobic and anaerobic bacteria including:

Dosage and administration Administration By the oral route. Synulox palatable tablets are often accepted from the hand even by sick cats and dogs. Alternatively, the tablets may be crushed and added to a little food. Dosage rate 12.5 mg/kg bodyweight. Dosage frequency The following table is intended as a guide to dispensing Synulox Palatable Tablets at the standard dose rate of 12.5 mg/kg, twice daily. For the majority of infections, including those of the skin, urinary tract and gastrointestinal tract, the above dosing regime is effective. Refractory cases, however, particularly those of the respiratory tract, have shown improved cure rates by doubling the dose to 25 mg/kg bodyweight twice daily. (Note that the smallest animals of 1 kg bodyweight when dosed with ½ tablet will already be receiving the doubled (25 mg/kg) dose rate.) Duration of therapy Routine cases involving all indications: The majority of these cases respond to between 5 and 7 days therapy.

Chronic or refractory cases In these cases, where there is considerable tissue damage, a longer course of therapy may be required in that it allows sufficient time for damaged tissue to repair. Based on clinical trials, the following durations are suggested as guidelines:

Contra-indications, warnings, etc For animal treatment only. Synulox Palatable Tablets should not be given to rabbits, guinea pigs, hamsters or gerbils. Caution is advised in their use in any other very small herbivores. Operator warning Penicillins and cephalosporins may cause hypersensitivity (allergy) following injection, inhalation, ingestion or skin contact. Hypersensitivity to penicillins may lead to cross reaction to cephalosporins and vice-versa. Allergic reaction to these substances may occasionally be serious. Do not handle this product if you know you are sensitised, or if you have been advised not to work with such preparations. Handle this product with great care to avoid exposure, taking all recommended precautions. If you develop symptoms following exposure such as skin rash, you should seek medical advice and show the doctor this warning. Swelling of the face, lips or eyes or difficulty with breathing are more serious symptoms, and may require urgent medical attention. Pharmaceutical precautions Do not store above 25°C. Store in a dry place. Keep out of the reach of children. Unused product and containers should be disposed of in accordance with national requirements.

Legal category POM-V (previously POM). Packaging Quantities Both size tablets are packed in foil strips containing 5×2 tablets. 50 mg tablets are supplied in packs of 100 and 500, 250 mg tablets are in packs of 100 and 250. Further information Resistance to many antibiotics is caused by beta-lactamase enzymes which destroy the antibiotic before it can act on the bacteria themselves. The clavulanate in Synulox counteracts this defence mechanism by inactivating the beta-lactamases, thus rendering the organisms sensitive to amoxicillin's rapid bactericidal effect, at concentrations readily attainable in the body. Synulox is effective against Klebsiella infections found in veterinary practice, but it is not indicated for cases involving Pseudomonas species. Synulox Palatable Tablets are often accepted from the hand, even by sick dogs and cats. Alternatively, the tablets may be crumbled and added to a little food. Synulox Palatable Tablets can safely be used during pregnancy and lactation. Synulox Palatable Drops are available as an alternative presentation for treating small individuals. Marketing authorisation numbers