Panacur Bolus (single)

Presentation
A cylindrical bolus consisting of 10 flat-faced tablets in two magnesium alloy tubes joined and enclosed by plastic rings. One bolus contains 12 grams of active ingredient fenbendazole and is designed to continuously release fenbendazole in the reticulo-rumen of cattle for up to 140 days.

Uses
The bolus treats and prophylactically controls gastro-intestinal nematode infections in cattle caused by Ostertagia spp., Trichostrongylus spp., Cooperia spp., Oesophagostomum spp. and Haemonchus spp. The bolus controls parasitic bronchitis caused by Dictyocaulus viviparus. For use in ruminating cattle weighing between 100 kg and 300 kg on day of administration. When administered at turnout, the bolus controls parasitic gastroenteritis throughout the grazing season by reducing the build up of infective larvae on the pasture. Reduced pasture contamination in the Autumn lowers the risk of inhibited Ostertagia larvae accumulating in sufficient numbers to cause winter ostertagiasis. When administered later in the season, the bolus is effective in the treatment of established parasitic infections and continues to have a prophylactic effect up to 140 days after administration. This period may be reduced if cattle are moved to heavily infected pasture.

Dosage and administration
One bolus to be administered orally to each animal before being turned out to grass.
Alternatively, animals which have already been turned out can be administered a bolus later in the grazing season.
All animals within a group grazing the same pasture must be treated with a Panacur Bolus to ensure maximum benefits from this system. All newcomers to the group must also be administered a Panacur Bolus before being turned out to grass.

Administration is achieved using the Panacur Bolus Applicator which helps to administer the bolus directly into the top of the oesophagus.
Insert a bolus into the applicator. Restrain the animal and extend the head forward, keeping the neck straight.
Insert the applicator into the front of the mouth and firmly but gently push it over the back of the tongue. Keeping the neck straight, tilt the head upwards and the animal will begin to swallow the end of the applicator – indicated by easier passage of the applicator down the throat. Take care not to insert the applicator too far down the throat. The bolus can then be ejected into the oesophagus by squeezing the release trigger on the applicator. Gently withdraw the applicator. Do not use force when administering the bolus.
Observe the animal for a short time after dosing to ensure the bolus has been swallowed.
As the metal of the bolus can be detected, the correct position of the bolus can be checked with a suitable metal detector.

Contra-indications, warnings, etc
Do not use in pre-ruminating cattle, cattle weighing less than 100 kg or cattle less than 3 months of age. Do not administer to cattle over 300kg. Do not administer to cattle producing milk for human consumption or to dairy heifers within 200 days prior to parturition.

Withdrawal period
Animals must not be slaughtered for human consumption during treatment. Cattle may be slaughtered for human consumption only after 200 days from administration of the bolus.
If lungworm vaccination is practised in cattle before turnout, the bolus should not be administered until 14 days after the second dose of vaccine has been given.
The bolus has not been evaluated for compatibility with other medicinal bolus products yet and therefore its use with other medicinal boluses is not recommended.

General precautions
Wash hands after use.
Intensive use or misuse of anthelmintics can give rise to resistance. To reduce this risk, dosing programmes should be discussed with your Veterinary Surgeon.
For animal treatment only. Keep out of reach of children.

Pharmaceutical precautions
Store in a dry place.

Legal category
POM-VPS (previously PML).

Packaging Quantities
Packs of 10×1 boluses.

Further information
Fenbendazole belongs to the benzimidazole (1-BZ) class of anthelmintics.
If a bolus-treated animal is sold during the season, the purchaser must be informed of the date on which the bolus was administered.
Immunity to nematodes depends on adequate exposure to infection. Although not normally the case, circumstances could occur in which anthelmintic control measures might increase the vulnerability of cattle to reinfection. Animals may be at risk towards the end of their first grazing season, particularly if the season is long, or in the following year if they are moved onto heavily contaminated pasture. In such instances, further control measures may be necessary.
Where specific preventative control of lungworm is required it is advised that cattle are treated with an appropriate lungworm vaccine. As Panacur Bolus allows a small percentage of lungworm to reach the lungs when cattle are exposed it will not interfere with the further development of immunity. Under conditions of heavy larval challenge, clinical signs of lungworm may become evident. Therefore, if clinical signs of lungworm occur in treated cattle they should be dosed immediately with an appropriate anthelmintic.
Without additional control measures, such as vaccination, lungworm infestations can sometimes develop during the active life of the bolus.
The bolus has been successfully used without undesirable effects in pregnant cows but it is not intended for use in this class of animal.
The bolus can interfere with the detection of foreign bodies (hardware disease) by an electronic metal detector.

Marketing authorisation number
Vm 01708/4447.