Oxytocin S-Hyperdrug

Presentation Clear, sterile, aqueous solution of Oxytocin PhEur equivalent to 10 i.u. per ml (0.18 mg/ml), for parenteral administration. Chlorbutanol PhEur 5 mg/ml is included as a preservative. Uses Injections of Oxytocin-S will initiate strong, regular and purposeful contractions of the uterine muscle especially in the later stages of pregnancy and post-partum. Oxytocin-S evokes the `let down' of milk although it has no action on the smooth muscles of the gut or urinary bladder, nor is it effective in the treatment of diabetes insipidus. The absence of vasopressor and antidiuretic effects make Oxytocin-S particularly suitable for obstetric use (stimulation of parturition, promotion of uterine involution and control of post-partum haemorrhage) and the treatment of agalactia. Oxytocin-S is indicated for: - stimulation of uterine contraction to facilitate parturition in the presence of a fully dilated cervix - to promote involution of the post-parturient uterus and thus aid the passage of retained placenta - to aid in the control of post-partum haemorrhage - promotion of milk `let-down' in cases of agalactia and to facilitate `stripping out' of infected quarters in the treatment of mastitis in cows.

Dosage and administration Oxytocin-S should normally be given by deep intramuscular injection.

Where the intravenous route is used, these doses should be reduced to one-quarter of the intramuscular dose and the injection given slowly at a dilution of 1 in 10 Water for Injections PhEur. Where speed of onset is not a priority, Oxytocin-S may be given by the subcutaneous route. A low initial dosage is recommended by any route as repeat administration is permissible. Large doses may be employed in post-parturient animals. Use with aseptic precautions.

Contra-indications, warnings, etc 1. When Oxytocin-S is used as an aid to parturition, cervical dilation must be confirmed prior to administration to prevent the risk of foetal death and possible uterine rupture. 2. Oxytocin-S is contra-indicated in any form of obstructive dystocia. 3. Excessive doses of the product may delay parturition by producing incoordinated uterine contractions which interfere with the progress of the foetus especially in multiple pregnancies. 4. The effects of daily dosages of 100 i.u. or more (to facilitate `stripping out' of infected quarters in the treatment of mastitis in cows) on the oestrous cycle have not been fully investigated and the cycle length may be altered. 5. Adrenaline at physiological levels markedly reduces effect of oxytocin on the uterus or mammary gland. For this reason the animal should not be frightened when complete oxytocin effect is desired to cause either milk `let-down' or uterine contractions. User warning Care should be taken to avoid accidental self-injection. Should self-injection occur, medical advice should be sought immediately. Women, particularly during lactation or the later stages of pregnancy, should avoid handling the product as it could cause smooth muscle (e.g. uterine) contraction. Withdrawal periods Cattle, horses, pigs, sheep and goats: Meat – zero days. Cattle, sheep and goats: Milk – zero days. For animal treatment only. Keep out of reach of children. Pharmaceutical precautions Store in a refrigerator (+2o and +8o C). Protect from light. Avoid the introduction of contamination during use. Following withdrawal of the first dose, use the product within 28 days. When the container is broached for the first time, the date on which any product remaining in the container should be discarded should be calculated. A statement of the in-use shelf life of the product is given on the packaging insert. This discard date should be written in the space provided on the label. Should any apparent growth or discolouration occur, the product should be discarded. Dispose of any unused product and empty containers in accordance with guidance from your local waste regulation authority.

Oxytocin S 25ml