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Orbeseal is indicated for the prevention of new intramammary infections throughout the dry period in cattle.
In cows likely to be free of sub-clinical mastitis, Orbeseal can be used on its own in dry cow management and mastitis control.
In cows that may have sub-clinical mastitis, Orbeseal may be used following administration of a suitable dry cow antibiotic treatment to the infected quarter.
Selection of cows for treatment with Orbeseal should be based on veterinary clinical judgement. Selection criteria may be based on the mastitis and cell count history of individual cows, or recognized tests for the detection of sub-clinical mastitis or bacteriological sampling.
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Presentation
Orbeseal is an off-white smooth paste, presented in syringes each containing 4 g intramammary suspension containing 65% bismuth subnitrate, in a mineral oil vehicle.
Uses
Orbeseal is indicated for the prevention of new intramammary infections throughout the dry period in cattle.
In cows likely to be free of sub-clinical mastitis, Orbeseal can be used on its own in dry cow management and mastitis control.
In cows that may have sub-clinical mastitis, Orbeseal may be used following administration of a suitable dry cow antibiotic treatment to the infected quarter.
Selection of cows for treatment with Orbeseal should be based on veterinary clinical judgement. Selection criteria may be based on the mastitis and cell count history of individual cows, or recognized tests for the detection of sub-clinical mastitis or bacteriological sampling.
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Dosage and administration
For intramammary infusion only.
Infuse the contents of one syringe of Orbeseal into each udder quarter immediately after the last milking of the lactation (at drying off). Do not massage the teat or udder after infusion of the product.
It is essential that the teat is thoroughly cleaned and disinfected with surgical spirit or alcohol-impregnated wipes. The teats should be wiped until the wipes are no longer visibly dirty. Teats should be allowed to dry prior to infusion. Infuse aseptically and take care to avoid contamination of the syringe nozzle. Following infusion it is advisable to use an appropriate teat dip or spray.
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Contra-indications, warnings, etc
It is important to observe strict aseptic technique for the administration of Orbeseal, because the product does not have antimicrobial activity.
Care must be taken not to introduce pathogens into the teat in order to reduce the risk of post-infusion mastitis.
Do not use Orbeseal alone in cows with sub-clinical mastitis at drying off. The compatibility of Orbeseal has only been shown with a cloxacillin-containing dry cow preparation.
Do not administer any other intramammary product following administration of Orbeseal.
Do not use in cows with clinical mastitis at drying off.
Do not use during lactation. If accidentally used in a lactating cow, a small (up to 2-fold) transient rise in somatic cell count may be observed. In such an event, strip out the seal manually. No additional precautions are necessary.
Under cold conditions the product may be warmed to room temperature in a warm environment, to aid syringeability. Individual syringes must not be placed in water.
Withdrawal periods
Meat: Zero days
Milk: Zero days
Operator warnings
Wash hands after use.
Pharmaceutical precautions
No special precautions are necessary for storage. Use the syringe only once.
Keep out of reach of children.
For animal treatment only.
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Legal category
POM-V
Packaging Quantities
24 syringe cartons and 120 syringe tubs are available.
Further information
It is good practice to observe dry cows regularly for signs of clinical mastitis. If a sealed quarter develops clinical mastitis, the affected quarter should be stripped out manually before appropriate therapy is instituted.
As Orbeseal is not absorbed following intramammary infusion, it can be used in pregnant animals. At calving the seal may be ingested by the calf and produces no adverse effects.
Orbeseal is not absorbed from the mammary gland, but forms a seal in the teat until physically removed. Infusion of Orbeseal into each udder quarter produces a seal in the teat that provides an immediate and long lasting physical barrier to entry of bacteria and other mastitis causing organisms.
Care must be taken not to introduce pathogens into the teat. It is essential that strict aseptic techniques are used for the infusion of Orbeseal as it possesses no antimicrobial activity. For best results the following steps are recommended:
1.All teats need to be thoroughly cleansed and disinfected prior to infusion of Orbeseal. Ensure sufficient time is allocated to treat each animal and do not combine this with other husbandry activities.
2.Ensure animals are appropriately restrained in hygienic conditions. Keep syringes clean and DO NOT immerse in water.
3.A separate pair of clean disposable gloves should be worn for the treatment of each cow.
4.Start with a visibly clean, dry teat and udder. If tears are obviously dirty then clean off dirt from teats only, with moistened disposable paper towels and dry thoroughly. Dip teats in a rapid-acting pre-dip, leave for 30 seconds, then wipe each teat completely dry with separate disposable paper towels. Strip fore milk into a strip cup and discard.
5.Thoroughly disinfect the whole surface of the teat with a disposable spirit/alcohol soaked swab. Studies indicate that the most effective means of teat cleaning involves the use of swabs freshly prepared from clean dry cotton wool soaked in surgical spirit (or the equivalent). If this is not available, then the supplied sterile swabs can be used. Clean the teats furthest away from you first, to avoid contaminating clean teats.
6.Gently scrub each teat end with new individual, disposable spirit/alcohol swabs, until both teat end and swab are visibly clean.
7.Grip the teat base firmly between your fingers at the junction with the udder. Turn the teat to a slight angle.
8.Remove the cap from the intramammary tube, being careful not to touch the nozzle. Infuse the contents of the syringe into the bottom portion of the teat below where you are pinching the teat avoiding contaminating the teat end. Infuse teats in the opposite order to cleaning, i.e. treat the quarters closest to you first. Do not massage the product into the udder.
9.Apply a post-milking teat disinfectant and confine the treated cows to a yard where they should stand for at least 30 minutes to allow the teat canal to close.
Failure to follow these recommendations can possibly lead to post-infusion mastitis, or in extreme cases, death.
After calving, the following steps are recommended for the effective removal of Orbeseal to minimise residues entering the milking machine.
1.Pinch teat at the top and strip quarter 10-12 times prior to first milking.
2.Strip foremilk and check for residues for first few milkings.
3.Inspect mastitis filters and milk sock for evidence of residues after every milking.
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