Noroclav-Hyperdrug

Noroclav 250 mg Tablets are for oral administration to dogs. Each Noroclav 250 mg Tablet contains Amoxicillin 200 mg (as Amoxicillin Trihydrate) and Clavulanic Acid 50 mg (as Potassium Clavulanate). Noroclav 250 mg Tablets are indicated for treatment of the following infections caused by b-lactamase producing strains of bacteria sensitive to amoxicillin in combination with clavulanic acid: •Skin infections (including superficial and deep pyodermas) caused by susceptible Staphylococci. •Urinary tract infections caused by susceptible Staphylococci or Escherichia coli. •Respiratory infections caused by susceptible Staphylococci. •Enteritis caused by susceptible Escherichia coli. It is recommended to carry out suitable tests for sensitivity testing when initiating the treatment. The treatment should only proceed if sensitivity is proven to the combination. In vitro potentiated amoxicillin is active against a wide range of clinically important aerobic and anaerobic bacteria including: Gram-positive: Staphylococci (including b-lactamase producing strains) Clostridia Streptococci Gram-negative: Escherichia coli (including most b-lactamase producing strains) Campylobacter spp Pasteurellae Proteus spp

Administration: By the oral route. The tablets may be crushed and added to a little food.

Dosage Rate: 12.5mg combined actives/kg bodyweight twice daily. The recommended dose of 12.5mg per kg is equivelant to one 250mg tablet per 20kg bodyweight.
Dosage frequency: The following table is intended as a guide to dispensing Noroclav 250mg Tablets at the standard dose rate of 12.5 mg/kg twice daily.

	Number if tablets per dose twice daily
Bodyweight (kg)	250mg
19-20	1
21-30	1 1/2
31-40	2
41-50	2 1/2
more than 50	3

Duration of therapy: Routine cases involving all indications: The majority of cases respond to between 5 and 7 days therapy.

Chronic or refractory cases: In these cases where there is considerable tissue damage, a longer course of therapy may be required in that it allows sufficient time for damaged tissue to repair.

For animal treatment only. Do not use in rabbits, guinea pigs, hamsters or gerbils. Do not use in animals with known hypersensitivity to penicillin or other substances of the beta-lactam group. Do not use in animals with serious dysfunction of the kidneys accompanied by anuria and oliguria. Do not use where resistance to this combination is known to occur. Hypersensitivity reactions unrelated to dose can occur with these agents. Gastrointestinal symptoms (diarrhoea, vomiting) may occur after administration of the product. Allergic reactions (e.g. skin reactions, anaphylaxia) may occasionally occur. In case of occurrence of allergic reaction, the treatment should be withdrawn. In animals with hepatic and renal failure, the dosing regimen should be carefully evaluated. Do not administer to horses and ruminating animals. Studies in laboratory animals have not produced any evidence of teratogenic effects. Use only according to the benefit/risk assessment by the responsible veterinarian during pregnancy and lactation. The potential for allergic cross-reactivity with other penicillins should be considered. Penicillins and cephalosporins may cause hypersensitivity (allergy) following injection, inhalation, ingestion or skin contact. Hypersensitivity to penicillins may lead to cross-reactions to cephalosporins and vice versa. Allergic reactions to these substances may occasionally be serious. Do not handle this product if you know you are sensitised, or if you have been advised not to work with such preparations. Handle this product with great care to avoid exposure, taking all recommended precautions. If you develop symptoms following exposure such as a skin rash, you should seek medical advice and show the doctor this warning. Swelling of the face, lips or eyes or difficulty with breathing are more serious symptoms and require urgent medical attention. Wash hands after use