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Difflam Sore Throat Rinse 200ml |
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Difflam Sore Throat Rinse can be used as a gargle or throat rinse to treat pain, soreness & swelling of the mouth and throat and discomfort of a throat
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Benzydamine Hydrochloride 0.15% w/v.
Difflam Sore Throat Rinse is a locally acting analgesic and anti-inflammatory treatment for the relief of painful inflammatory conditions of the throat including pharyngitis.
Benzydamine exerts an anti-inflammatory and analgesic effect by stabilising the cellular membrane and inhibiting prostaglandin synthesis.
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Adults: Rinse or gargle with 15ml (using measuring cup provided) every 1½ to 3 hours as required for pain relief.
The solution should be expelled from the mouth after use.
Children: Not suitable for children aged 12 years or under.
Elderly: No special dosage recommendations are made for elderly patients.
Uninterrupted treatment should not exceed seven days, except under medical supervision.
Overdose
Difflam Sore Throat Rinse is unlikely to cause adverse systemic effects, even if accidental ingestion should occur. No special measures are required.
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Difflam Sore Throat Rinse is contra-indicated in patients with known hypersensitivity to any of the ingredients.
Difflam Sore Throat Rinse should generally be used undiluted, but if 'stinging' occurs the rinse may be diluted with water. Avoid contact with the eyes.
There is inadequate evidence of safety of the drug in human pregnancy, but it has been in wide use for many years without apparent ill consequence.Side-effects are minor. Occasionally, oral tissue numbness or 'stinging' sensations may occur. Hypersensitivity reactions occur very rarely but may be associated with pruritus rash, urticaria, photodermatitis and occasionally laryngospasm or bronchospasm.
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Oral doses of benzydamine are well absorbed and plasma drug concentrations reach a peak fairly rapidly and then decline with a half-life of about 13 hours. Less than 20% of the drug is bound to plasma proteins.
Although local drug concentrations are relatively large, the systemic absorption of mouthwash-gargle doses of benzydamine is relatively low compared to oral doses. This low absorption should greatly diminish the potential for any systemic drug side-effects when benzydamine is administered by this route. Benzydamine is metabolized primarily by oxidation, conjugation and dealkylation.
List of excipients
Ethanol (96% v/v) BP Glycerol Ph Eur, Saccharin Sodium BP, Mouthwash Flavour, 52 503/T, Polysorbate 20 Ph Eur, Methyl Hydroxybenzoate Ph Eur, Quinoline Yellow (E104), Patent Blue V (E131), Purified Water Ph Eur.
Store between 5°C and 30°C; do not freeze; do not leave uncartonned bottle in direct sunlight
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