Denagard is an oral antibiotic for pigs and poultry-Hyperdrug

Product Type

Oral antibiotic intended for preventive and therapeutic use in pigs and poultry.

Description and Composition

DENAGARD 12.5% Solution is an aqueous solution containing 125 mg tiamulin hydrogen fumarate per ml of product. It is used for medication in drinking water.

Properties

Tiamulin is a bacteriostatic agent, belonging to the group of pleuromutilins and acts at the ribosomal level to inhibit bacterial protein synthesis. It has a wide spectrum of activity but is particularly active against Brachyspira, Lawsonia and Mycoplasma species. Tiamulin belongs to a category of antibiotics which is not used in human medicine.

Indications

Treatment and prevention of Mycoplasma infections (enzootic pneumonia, chronic respiratory disease), pleuropneumonia and porcine respiratory disease complex.

Denagard is particularly indicated for the treatment of swine dysentery (B.hyodysenteriae)

Dosage and Administration

Pigs:

Treatment of swine dysentery: 8.8 mg tiamulin hydrogen fumarate / kg bodyweight (equivalent to 10 ml DENAGARD 12.5% Solution per 142 kg bodyweight; inclusion level 0.006% tiamulin) for 3-5 consecutive days
Treatment of PRDC (porcine respiratory disease complex): 15 – 20 mg tiamulin hydrogen fumarate / kg bodyweight (inclusion level 0.012% - 0.018% tiamulin) for 5 – 10 consecutive days
Treatment of pleuropneumonia: 20 mg tiamulin hydrogen fumarate / kg bodyweight (inclusion level 0.018% tiamulin) for 5 consecutive days

Indications	Tiamulin (concentration in water in %)	Product (in ml)	Water (in liters)	Treatment (in days)
Treatment swine dysentery	0.006	1	2.1	5
Treatment PRDC	0.012 / 0.018	1	1.0 / 0.7	5 - 10
Treatment pleuropneumonia	0.018	1	0.7	5

Chickens:

Prevention of chronic respiratory disease (CRD) and air sacculitis: 12.5 mg tiamulin hydrogen fumarate / kg bodyweight
Treatment of chronic respiratory disease (CRD) and air sacculitis: 25 mg tiamulin hydrogen fumarate / kg bodyweight

Turkeys:

Prevention of infectious sinusitis and air sacculitis: 12.5 mg tiamulin hydrogen fumarate / kg bodyweight
Treatment of infectious sinusitis and air sacculitis: 25 mg tiamulin hydrogen fumarate / kg bodyweight

Indications	Tiamulin (concentration in water in %)	Product (in ml)	Water (in liters)	Treatment (in days)
Prevention CRD / air sacculitis / infectious sinusitis	0.0125	1	1	3 days (1st week of life); 1-2 days every 3-4 weeks
Treatment CRD / air sacculitis / infectious sinusitis	0.025	2	1	3 – 5

Withdrawal Periods

Withdrawal periods according to national registrations.

Withdrawal Periods

Withdrawal periods according to national registrations.

Special Precautions and Warnings

Do not administer ionophore anticoccidials (salinomycin, monensin, narasin) to pigs and poultry receiving therapeutic doses of DENAGARD. Pigs and poultry should not receive products containing ionophores during or for at least seven days before or after treatment with DENAGARD.

Formulations and Packages

DENAGARD 12.5% Solution

1 litre dispensing packs

Denagard Solution 12.5% 1L