Carprodolor 50 mg/ml solution for injection 50ml

Carprodolor 50 mg/ml solution for injection 50ml


Be the first to review this item

Item Number: CARPRODIN 
Phone orders quick webcode: 

Unit Price:

£52.39 (Incl. Vat)

Usually despatched within 24 hours

Quantity

NB This is a prescription only medicine
How do I buy Prescription medicines from you?

  1. Obtain a Prescription from your vet
  2. Place your order online or by phone
  3. Write the order number on the top of the prescription and post it to us.
  4. Choose your delivery method. Either Royal Mail Special Delivery which operates a next working day service, requiring a signature(Our recommended option). Or First class post which is free and is usually next working day but may take longer.
  5. Hyperdrug Pharmaceuticals Ltd, Middleton In Teesdale, Barnard Castle, County Durham, DL12 0NG.

Can I send a faxed prescription or a photocopy?

No a prescription is a legal document which must be written according to UK regulations and signed and dated by a vet with UK registration. Photocopies or electronic copies are not valid.

X

The item you are adding to your basket requires a prescription before we can send the item to you but don't worry you can do this in 3 easy steps:

  1. Place your order online or by phone
  2. Obtain a Prescription from your vet
  3. Write the order number on the top of the prescription and post it to us.

 I have a prescription on file
 I am sending you a prescription in the post

As soon as your prescription is received your card will be charged and the medicine sent



Description

Carprodolor 50 mg/ml solution for injection 50ml.

Target species
Cattle

Indications for use,specifying the target species
The product is indicated as an adjunct to antimicrobial therapy to reduce clinical signs in acute infectious respiratory disease and acute mastitis in cattle.

Contraindications
Do not use in animals suffering from cardiac, hepatic or renal impairment.
Do not use in animals suffering from gastro-intestinal ulceration  or bleeding.
Do not use where there is evidence of a blood dyscrasia.
Do not use in cases of hypersensitivity to the active substance or to any of the excipients.

Special warnings
None

Special precautions for use
i. Special precautions for use in animals

Avoid use in any dehydrated, hypovolaemic or hypotensive animal, as there is a potential risk of increased renal toxicity. Concurrent administration of potentially nephrotoxic drugs should be avoided.

Do not exceed the stated dose or the duration of treatment.

Do not administer other NSAID's concurrently or within 24 hours of each other.

As NSAID therapy can be accompanied by GI or renal impairment, adjunctive fluid therapy should be considered especially in the case of acute mastitis treatment.

ii. Special precautions to be taken by the person administering the veterinary medicinal product to animals

Carprofen, in common with other NSAIDs, has been shown to exhibit photosensitising potential in laboratory studies.  Avoid skin contact with the veterinary medicinal product. Should this occur, wash the affected areas immediately.

Take care to avoid accidental self-injection.  In the event of accidental self-injection seek medical advice immediately.

Adverse reactions (frequency and seriousness)
Studies in cattle have shown that a transient local reaction may form at the site of the injection.

Use during pregnancy, lactation or lay
In the absence of any specific studies in pregnant cattle, use only after a risk/benefit assessment has been performed by the attending veterinary surgeon.

Interaction with other medicinal products and other forms of interaction
No specific significant drug interactions have been reported for carprofen. During clinical studies in cattle four different antibiotic classes were used, macrolides, tetracyclines, cephalosporins and potentiated penicllins without known interactions.   However, in common with other NSAIDs, carprofen should not be administered simultaneously with another veterinary medicinal product of the NSAID or glucocorticoid class.  Animals should be carefully monitored if carprofen is administered simultaneously with an anticoagulant.

NSAID's are highly bound to plasma proteins and may compete with other highly bound drugs, such that concomitant administration may result in toxic effects.

Amounts to be administered and administration route
Single subcutaneous or intravenous injection at a dosage of 1.4 mg carprofen/ kg body weight (1 ml/35 kg) in combination with antibiotic therapy, as appropriate.

The stopper should not be punctured more than 20 times.

Overdose (symptoms, emergency procedures, antidotes), if necessary
In clinical studies, no adverse signs were reported after intravenous and subcutaneous administration of up to 5 times the recommended dose. 

There is no specific antidote for carprofen overdosage but general supportive therapy, as applied to clinical overdosage with NSAID's, should be applied.

Withdrawal period(s)
Meat and offal: 21 days
Milk:    Zero hours

PHARMACOLOGICAL PROPERTIES
Pharmacotherapeutic group: Anti-inflammatory and Anti-rheumatic products, non-steroids
ATCvet code:  QM01AE91

Pharmacodynamic properties
Carprofen is a member of the 2-arylpropionic acid group of non-steroidal anti-inflammatory drugs (NSAID's), and possesses anti-inflammatory, analgesic and antipyretic activity. 

Carprofen, like most other NSAID's is an inhibitor of the enzyme cyclo-oxygenase of the arachidonic acid cascade. However, the inhibition of prostaglandin synthesis by carprofen is slight in relation to its anti-inflammatory and analgesic potency. The precise mode of action is unclear.

Studies have shown that carprofen has potent antipyretic activity and significantly reduces the inflammatory response in lung tissue in cases of acute, pyrexic infectious respiratory disease in cattle. Studies in cattle with experimentally induced acute mastitis have shown that carprofen administered intravenously has potent antipyretic activity and improves heart rate and rumen function.

Pharmacokinetic particulars
Absorption: Following a single subcutaneous dose of 1.4 mg carprofen/kg the maximum plasma concentration (Cmax) of 15.4 ?g/ml was reached after (Tmax) 7-19 hours.

Distribution: The highest carprofen concentrations are found in bile and plasma and more than 98% of carprofen is bound to plasma proteins. Carprofen was well distributed in the tissues with the highest concentrations found in kidney and liver followed by fat and muscle.

Metabolism: Carprofen (parent) is the main component in all tissues. Carprofen (parent compound) is slowly metabolised primarily by ring hydroxylation, hydroxylation at the ?-carbon and by conjugation of the carboxylic acid group with glucuronic acid. The 8-hydroxylated metabolite and unmetabolized carprofen predominate in the faeces. Bile samples are comprised of conjugated carprofen.

Elimination: Carprofen has a plasma elimination half-life of 70 hours. Carprofen is primarily excreted in the faeces, indicating that the biliary secretion plays an important role.

PHARMACEUTICAL PARTICULARS
List of excipients
Ethanol 96%
Macrogol 400
Poloxamer 188
Ethanolamine
Water for injection

Incompatibilities
In the absence of compatibility studies, this veterinary medicinal product must not be mixed with other veterinary medicinal products.

Shelf life
Shelf-life of the veterinary medicinal product as packaged for sale: 3 years
Shelf-life after first opening the immediate packaging: 28 days

Special precautions for storage
Do not refrigerate or freeze
Keep the vial in the outer carton in order to protect from light.

Nature and composition of immediate packaging
50 ml amber glass (Type I) vials capped with chlorbutyl rubber stopper retained by an aluminium crimped seal in a cardboard box.

Special precautions for the disposal of unused veterinary medicinal product or waste materials derived from the use of such products
Any unused veterinary medicinal product or waste materials derived from such veterinary medicinal products should be disposed of in accordance with local requirements

Delivery

Free shipping from Hyperdrug

Value Weight Delivery Charge*  
Over £49.00 Any Weight FREE*
Under £49.00 Under 250g £2.49
Under £49.00 No weight limit £4.99

Most orders are despatched the same day and standard delivery is 3 to 5 working days from despatch. FAST Expedited delivery options are available.

Estimated " Usually shipped in" information is shown against most products

 

Due to the large volume of parcels Royal Mail and Parcel Force handle over the Christmas period, we advise you give as much time as possible to receive your goods. Please ensure you order any essentials, such as prescription only medicines and diets, as soon as possible for UK delivery before Christmas. 
 
Last posting dates to expect goods before Christmas
Royal Mail - Wednesday 14th December
Parcel Force - Friday 16th December
Fast Track - Wednesday 21st December
 
Hyperdrug.co.uk website is open 24 hours a day, 7 days a week.
 
Office Opening hours 
Monday 19th - Friday 23rd - OPEN 8am - 5.30pm
Saturday 24th - Tuesday 27th - CLOSED
Wednesday 28th - Friday 30th - OPEN 8am - 5.30pm
Saturday 31st - Monday 2nd - CLOSED
Tuesday 3rd - Friday 6th - OPEN 8am - 5.30pm
Saturday 7th - OPEN 9am - 4pm

Overseas orders

Postage outside of the UK is from £4.95

Finding out delivery Charges and options before checkout

  1. Simply add an item to your basket
  2. Click view basket/Cart
  3. Click estimate shipping charges
*Free delivery and selected charges on orders over £49.00 mainland UK Parcelforce Zone1 for more information check the delivery info page.
 
 

Reviews

Click here for the product datasheet