CaniLeish Suspension for Injection for Dogs (3 dose)

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CaniLeish Suspension for Injection for Dogs (3 dose)


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Item Number: CANILEISH 
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Unit Price:

£126.65 (Incl. Vat)

Usually despatched within 24 hours

Quantity

NB This is a prescription only medicine
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  1. Obtain a Prescription from your vet
  2. Place your order online or by phone
  3. Write the order number on the top of the prescription and post it to us.
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  5. Hyperdrug Pharmaceuticals Ltd, Middleton In Teesdale, Barnard Castle, County Durham, DL12 0NG.

Can I send a faxed prescription or a photocopy?

No a prescription is a legal document which must be written according to UK regulations and signed and dated by a vet with UK registration. Photocopies or electronic copies are not valid.

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Description

CaniLeish Suspension for Injection for Dogs (3 dose).

Target species

Dogs

Indications for use

For the active immunization of Leishmania negative dogs from 6 months of age to reduce the risk to develop an active infection and clinical disease after contact with Leishmania infantum.

The efficacy of the vaccine has been demonstrated in dogs submitted to multiple natural parasite exposure in zones with high infection pressure.

Onset of immunity: 4 weeks after the primary vaccination course.

Duration of immunity: 1 year after the last (re-)vaccination.

Contra-indications

Do not use in case of hypersensitivity to the active substance, to the adjuvant or to any of the excipients.

Special warnings for each target species

Transient antibodies against Leishmania detected by immunofluorescence antibody test (IFAT) may appear after vaccination. Antibodies due to vaccination can be differentiated from antibodies due to natural infection by using a rapid diagnostic serological test as a first step to a differential diagnosis. In areas of low or no infection pressure a benefit/risk assessment must be undertaken by the veterinarian before deciding to use the vaccine in dogs.

The impact of the vaccine in terms of public health and control of the human infection cannot be estimated from available data.

Special precautions for use

Special precautions for use in animals

Vaccinate only healthy animals. The efficacy of vaccination in dogs already infected has not been investigated and therefore cannot be recommended. In dogs developing a leishmaniosis (active infection and/or disease) despite vaccination, proceeding with vaccine injections showed no benefit. Injection of the vaccine to dogs already infected by Leishmania infantum did not show any specific adverse reactions other than those described in section 4.6. The detection of Leishmania infection using a rapid serological diagnostic test is recommended prior to vaccination.

In case of anaphylactic reaction appropriate symptomatic treatment should be administered.

De-worming of infested dogs prior to vaccination is recommended.

Vaccination should not prevent other measures taken to reduce exposure to sandflies.

Special precautions to be taken by the person administering the veterinary medicinal product to animals

In case of accidental self-injection, seek medical advice immediately and show the package leaflet or the label to the physician.

Adverse reactions

After injection, moderate and transient local reactions may occur such as swelling, nodule, pain on palpation or erythema. These reactions resolve spontaneously within 2 to 15 days. Other transient signs commonly seen following vaccination may be observed such as hyperthermia, apathy and digestive disorders lasting 1 to 6 days. Allergic-type reactions are uncommon and appropriate symptomatic treatment should then be administered.

Use during pregnancy, lactation or lay

The safety of the veterinary medicinal product has not been established during pregnancy and lactation. Therefore, the use is not recommended during pregnancy and lactation.

Interactions

No information is available on the safety and efficacy of this vaccine when used with any other veterinary medicinal product. A decision to use this vaccine before or after any other veterinary medicinal product therefore needs to be made on a case by case basis.

Amounts to be administered and administration route

Subcutaneous use.

After reconstitution of the lyophilisate with the solvent, shake gently and administer immediately one dose of 1 ml subcutaneously according to the following vaccination schedule:

Primary vaccination course:

-First dose from 6 months of age,

-Second dose 3 weeks later,

-Third dose 3 weeks after the 2nd injection.

Annual re-vaccination:

One booster injection of a single dose should be given 1 year after the third injection and annually thereafter.

Overdose

No adverse reactions other than those mentioned above were observed after the administration of a double-dose of the vaccine.

Withdrawal periods

Not applicable

Pharmacological particulars

Immunological properties

Pharmacotherapeutic group: Immunologicals for canidae – dog – inactivated parasitic vaccine.

ATC vet code : QI07AO.

Vaccination induces a cell-mediated immunity evidenced by:

•the appearance of specific IgG2 antibodies to Leishmania infantum excreted secreted proteins,

•an enhancement of the leishmanicidal activity of the macrophages,

•a T-cell lymphoproliferation with the secretion of interferon gamma cytokine,

•a positive T-cell-mediated immune response, directed against the Leishmanian antigen (skin test).

Efficacy data have shown that a vaccinated dog has 3.6 times less risk to develop an active infection and 4 times less risk to develop a clinical disease than a non-vaccinated dog, on dogs submitted to multiple natural parasite exposure in zones with high infection pressure.

Pharmaceutical particulars

List of excipients

Lyophilisate

Purified extract of Quillaja saponaria (QA-21)

Trometamol

Sucrose

Mannitol

Solvent

Sodium chloride 9 mg/ml (0.9%)

Water for injections

Major incompatibilities

In the absence of compatibility studies, this veterinary medicinal product must not be mixed with other veterinary medicinal products.

Shelf life

Shelf life of the veterinary medicinal product as packaged for sale: 2 years.

Shelf life after first opening the immediate packaging: use immediately after reconstitution.

Special precautions for storage

Store and transport refrigerated (2°C – 8°C).

Protect from light.

Immediate packaging

Type I glass vial containing 1 dose of lyophilisate and type I glass vial containing 1 ml of solvent,

both closed with a butyl elastomer closure and sealed with an aluminium cap.

Pack sizes:

Box containing 3 vials of 1 dose of lyophilisate and 3 vials of 1 ml of solvent.

Disposal

Any unused veterinary medicinal product or waste materials derived from such veterinary medicinal products should be disposed of in accordance with local requirements.

Delivery

Free shipping from Hyperdrug

Value Weight Delivery Charge*  
Over £49.00 Any Weight FREE*
Under £49.00 Under 250g £2.49
Under £49.00 No weight limit £4.99

Most orders are despatched the same day and standard delivery is 3 to 5 working days from despatch. FAST Expedited delivery options are available.

Estimated " Usually shipped in" information is shown against most products

 

Due to the large volume of parcels Royal Mail and Parcel Force handle over the Christmas period, we advise you give as much time as possible to receive your goods. Please ensure you order any essentials, such as prescription only medicines and diets, as soon as possible for UK delivery before Christmas. 
 
Last posting dates to expect goods before Christmas
Royal Mail - Wednesday 14th December
Parcel Force - Friday 16th December
Fast Track - Wednesday 21st December
 
Hyperdrug.co.uk website is open 24 hours a day, 7 days a week.
 
Office Opening hours 
Monday 19th - Friday 23rd - OPEN 8am - 5.30pm
Saturday 24th - Tuesday 27th - CLOSED
Wednesday 28th - Friday 30th - OPEN 8am - 5.30pm
Saturday 31st - Monday 2nd - CLOSED
Tuesday 3rd - Friday 6th - OPEN 8am - 5.30pm
Saturday 7th - OPEN 9am - 4pm

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