Benylin Chesty Coughs - soothing effect-Hyperdrug

BENYLIN® Chesty Coughs Original provides deep penetrating relief and a soothing effect that allows you to get on with your day.

Active ingredient diphenhydramine hydrochloride is an antihistamine and works by relieving a cough.

Diphenhydramine also helps dry nasal secretions by preventing the natural body chemical histamine from binding to its receptors and producing a runny nose.

Levomenthol works to relieve stuffiness in the nose to help make breathing easier.

Chesty coughs are caused by a build-up of phlegm in the lungs and on the chest.

The cough mechanism kicks in to try and get rid of this excess mucus.

Each 5ml of cough medicine contains 14mg diphenhydramine hydrochloride and 2mg levomenthol.

For oral use Adults and Children aged 12 years and over: One 10 ml dose of syrup 4 times a day. Maximum daily dose: 40 ml syrup. Children under 12 years: Benylin Chesty Coughs (Original) is contraindicated in children under the age of 12 years (see section 4.3). The Elderly: As for adults above (see Pharmacokinetics - The elderly). Hepatic dysfunction Caution should be exercised if moderate to severe hepatic dysfunction is present (see Pharmacokinetics - Hepatic dysfunction). Renal dysfunction It may be prudent to increase the dosage interval in subjects with moderate to severe renal failure (see Pharmacokinetics - Renal dysfunction). Do not exceed the stated dose. Keep out of the reach and sight of children.

BENYLIN CHESTY COUGHS (ORIGINAL) is contraindicated in individuals with known hypersensitivity to the product or any of its constituents. Benylin Chesty Coughs (Original) is contraindicated in individuals with chronic or persistent cough, such as occurs with asthma, or where cough is accompanied by excessive secretions, unless directed by the physician. Benylin Chesty Coughs (Original) should not be administered to patients currently receiving monoamine oxidase inhibitors (MAOI) or those patients who have received treatment with MAOIs within the last two weeks. Not to be used in children under the age of 12 years. This product may cause drowsiness. If affected individuals should not drive or operate machinery. Subjects with moderate to severe renal or hepatic dysfunction or urinary retention should exercise caution when using this product (see Pharmacokinetics - Renal/Hepatic Dysfunction). This product contains diphenhydramine and therefore should not be taken by individuals with narrow-angle glaucoma or symptomatic prostatic hypertrophy. Patients with rare hereditary problems of fructose intolerance, glucose-galactose malabsorption or sucrase-isomaltase insufficiency should not take this medicine This product contains diphenhydramine and therefore may potentiate the effects of alcohol, codeine, antihistamines and other CNS depressants. As diphenhydramine possesses some anticholinergic activity, the effects of anticholinergics (eg, some psychotropic drugs and atropine) may be potentiated by this product. This may result in tachycardia, dry mouth, gastrointestinal disturbances (eg, colic), urinary retention and headache. Although diphenhydramine has been in widespread use for many years without ill consequence, it is known to cross the placenta and has been detected in breast milk. BENYLIN CHESTY COUGHS (ORIGINAL) should therefore only be used when the potential benefit of treatment to the mother exceeds any possible hazards to the developing foetus or suckling infant.

Side effects associated with the use of BENYLIN CHESTY COUGHS (ORIGINAL) are uncommon. Diphenhydramine may cause drowsiness; dizziness; gastrointestinal disturbance; dry mouth; nose and throat; difficulty in urination or blurred vision. Less frequently it may cause palpitations, tremor, convulsions or parasthesia. Hypersensitivity reactions have been reported, in particular, skin rashes, erythema, urticaria and angiodema. Adverse reactions to menthol at the low concentration present in BENYLIN CHESTY COUGHS (ORIGINAL) are not anticipated. Pharmacodynamic properties Diphenhydramine possesses antitussive, antihistaminic and anticholinergic properties. Experiments have shown that the antitussive effect (resulting from an action on the brainstem) is discrete from its antihistaminic effect. The duration of activity of diphenhydramine is between 4 and 8 hours. Menthol has mild local anaesthetic and decongestant properties. Pharmacokinetic properties Absorption Diphenhydramine and menthol are well absorbed from the gut following oral administration. Peak serum levels of diphenhydramine following a 50 mg oral dose are reached at between 2 and 2.5 hours. Distribution Diphenhydramine is widely distributed throughout the body, including the CNS. Following a 50 mg oral dose of diphenhydramine, the volume of distribution is in the range 3.3 - 6.8 l/kg, and it is some 78% bound to plasma proteins. Metabolism and Elimination Diphenhydramine undergoes extensive first pass metabolism. Two successive N-demethylations occur, with the resultant amine being oxidised to a carboxylic acid. Values for plasma clearance of a 50 mg oral dose of diphenhydramine lie in the range 600-1300 ml/min and the terminal elimination half-life lies in the range 3.4 - 9.3 hours. Little unchanged drug is excreted in the urine. Menthol is hydroxylated in the liver by microsomal enzymes to p-methane-3,8 diol. This is then conjugated with glucuronide and excreted both in urine and bile as the Glucuronide. The Elderly Pharmacokinetic studies indicate no major differences in distribution or elimination of Diphenhydramine compared to younger adults. Renal Dysfunction The results of a review on the use of Diphenhydramine in renal failure suggest that in moderate to severe renal failure, the dose interval should be extended by a period dependent on Glomerular filtration rate (GFR). Hepatic Dysfunction After intravenous administration of 0.8 mg/kg Diphenhydramine, a prolonged half-life was noted in patients with chronic liver disease which correlated with the severity of the disease. However, the mean plasma clearance and apparent volume of distribution were not significantly affected. List of excipients Ammonium chloride Liquid glucose Sucrose Ethanol 96% Glycerol Sodium citrate Saccharin sodium Citric acid monohydrate Sodium benzoate Caramel T12 Raspberry flavour 503.850/T Carbomer Ponceau 4R (E124) Purified water

Benylin Chesty Coughs Original 300ml