Baycox 2.5% for the treatment of coccidiosis in broilers-Hyperdrug

Presentation A clear colourless to yellow brown solution containing as active ingredient 2.5% w/v (25 mg/ml) toltrazuril for dilution in drinking water and subsequent administration. The product also contains the following excipients, triethanolamine 30 mg/ml and polyethylene glycol 80.7 mg/ml. Uses For the treatment of coccidiosis in Broilers and Broiler Breeders. Baycox 2.5% Solution is effective against Eimeria acervulina, E. brunetti, E. maxima, E. necatrix, E. tenella, E. mitis.

Dosage and administration Administration: via the drinking water Baycox is mixed in the drinking water before use. Gentle mixing is required. Proportioning systems may be used (see Pharmaceutical Precuations). The recommended dose rate is 7 mg toltrazuril per kg bodyweight per day given for 2 consecutive days. This corresponds to: 28 ml Baycox 2.5% Solution (equivalent to 700 mg toltrazuril) per 100 kg of bodyweight per day for 2 consecutive days. To calculate the volume of Baycox required to be added to the water supply over one day. Total liveweight in kg x 0.28 = ml Baycox required for one day As a guide for usage this is normally equivalent to 25 ppm (equivalent to 1 ml Baycox 2.5% Solution) per litre of drinking water for continuous medication over 48 hours, or to 75 ppm (equivalent to 3 ml Baycox 2.5% Solution) per litre of drinking water given for 8 hours per day, on 2 consecutive days. Treatment Regimen Curative Treatment Chicken: 1 medication period (over 2 days) which can be repeated after 5 days in case of severe infections. Only make up sufficient drinking water for requirements. After calculations of the required amount of product, this volume should be carefully dispensed from the container into a domestic measuring jug reserved and labeled specifically for the purpose. Measurement must be made carefully to ensure correct dosage. Product must not be stored in the jug.

Contra-indications, warnings, etc Do not use in birds producing eggs for human consumption. Consumer Safety Do not slaughter birds for human consumption during treatment or for a period of 18 days following last administration. User Safety Baycox is an alkaline solution. Wear synthetic rubber gloves when handling the product. Wash any splashes from skin and eyes immediately with water. Wash hands and exposed skin after use. Do not eat, drink or smoke whilst using the product. Environmental Safety: Only make up sufficient drinking water for requirements. Wash out empty container with water 3 times when medicating birds and add washings to drinking water. Store litter from treated houses as long as possible. Do not apply to agricultural land at a rate greater than 2 tonnes/hectare/year. If spreading within an NVZ ensure that the NVZ action program rules are complied with. The principle metabolite of toltrazuril is persistent and mobile in groundwater. Disposal of manure from treated birds of all species is therefore likely to require prior authorisation from the local environmental regulatory authority. The local office of the Environment Agency, SEPA or Environment and Heritage Service of Northern Ireland should be contacted in good time before disposing of manure from treated birds. Any unused product or waste material should be disposed of in accordance with national requirements. Pharmaceutical precautions Dilutions more concentrated than 1:1,000 (1 ml Baycox 2.5% to 1 litre drinking water) may result in precipitation. Predilution is not recommended. Do not store above 25°C. Following dilution in drinking water Baycox is stable for 24 hours. Any medicated water which is not consumed within 24 hours should be discarded safely.

Legal category POM-V (previously POM) Packaging Quantities 1 litre high density polyethylene bottles, containing solution for dilution in water. Further information Anticoccidial, active against all intracellular stages but the mode of action is unknown. In poultry toltrazuril is absorbed at a rate of at least 50%. The highest equivalent concentrations are found in liver. The active substance is rapidly metabolised in poultry. The main metabolite is characterised as a sulfone-derivative. About 1 week after the last dose this metabolite represents by far the most relevant residue in the animal. Baycox is compatible with coccidiostats and amoebostats. A three-five fold overdosage is readily tolerated without any symptoms. If the recommended dose is exceeded beyond 3-5 times there is a decrease in water intake. Baycox does not interfere with the development of immunity against coccidiosis. As with all anticoccidials, prolonged use may result in the development of resistant strains. Marketing authorisation number Vm 00010/4084.

Baycox 2.5% Oral Solution 1L