Amoxinsol 50 for treatment of pasteurellosis-Hyperdrug

Presentation A soluble powder for oral use containing Amoxycillin Trihydrate PhEur 50% with Anhydrous Citric Acid PhEur as diluent. Uses Chickens For the treatment of pasteurellosis and colibacillosis. Turkeys For the treatment of pasteurellosis. Ducks For the treatment of infections caused by Streptococcus bovis, Pasteurella anatipestifer and Escherichia coli. Pigs For the treatment of salmonellosis and pasteurellosis.

Dosage and administration Amoxinsol 50 is administered in the drinking water. Prepare the solution with fresh tap water. In order to ensure consumption of the medicated water, animals should not have access to other water supplies whilst on treatment. Chickens Dissolve the contents of 1 sachet (150 g of the product) in 450 litres (100 gallons) of water immediately before use. This will provide medication for 5000 kg bodyweight of birds for 1 day (15 mg amoxycillin trihydrate per kilogram bodyweight). As a guide, 1 sachet of Amoxinsol 50 will treat the following number of birds. Age in weeks No. of birds 1 30,000 2 13,500 3 7,500 4 5,000 6 3,000 8 2,000 Amoxinsol 50-medicated drinking water should be provided on alternate days. The total period of treatment should be for 3 days (2 days of medication) or in severe cases for 5 days (3 days of medication). Ducks Administer in the drinking water to give 20 mg amoxycillin trihydrate/kg bodyweight. Medication should be provided on alternate days for 3 days, i.e. 2 days of medication. Because of the variable water intake of ducks, depending on temperature, light and feeding regime, exact recommendation on dilution of the product cannot be given. In each case the quantities of Amoxinsol 50 to be used must be calculated taking into account the water intake and total bodyweight of the birds involved. Turkeys Administer in the drinking water to give 15–20 mg amoxycillin trihydrate/kg bodyweight. Medication to be provided on alternate days for 5 days (medication on days 1, 3 and 5). Dosage should be calculated taking into account normal water intake and total bodyweight of birds. Pigs Administer in the drinking water to give 20 mg amoxycillin trihydrate/kg bodyweight daily, this corresponds to 40mg of Amoxinsol 50/kg. The dose should be divided and administered at approximately 12 hourly intervals for up to 5 days.

Contra-indications, warnings, etc Amoxinsol 50 should not be administered to rabbits, hamsters, gerbils and guinea pigs, or birds producing eggs intended for human consumption. Withdrawal periods Animals must not be slaughtered for human consumption during treatment. Chickens may be slaughtered for human consumption only after 48 hours from last treatment. Ducks may be slaughtered for human consumption only after 9 days from last treatment. Turkeys may be slaughtered for human consumption only after 5 days from last treatment. Pigs may be slaughtered for human consumption only after 48 hours from last treatment. For animal treatment only. Keep out of reach of children. Operator warning Avoid inhalation of dust. Wash hands after use. Penicillins and cephalosporins may cause hypersensitivity (allergy) following injection, inhalation, ingestion or skin contact. Hypersensitivity to penicillins may lead to cross reactions to cephalosporins and vice versa. Allergic reactions to these substances may occasionally be serious. Do not handle this product if you know you are sensitised, or if you have been advised not to work with such preparations. Handle this product with great care to avoid exposure, taking all recommended precautions. If you develop symptoms following exposure such as a skin rash, you should seek medical advice and show the doctor this warning. Swelling of the face, lips or eyes or difficulty with breathing are more serious symptoms and require urgent medical attention. Pharmaceutical precautions Do not store above 25°C. Store in a dry place. Any medicated water which is not consumed within 12 hours should be discarded. Spillages should be washed away with copious amounts of water. Any unused product or waste material should be disposed of in accordance with national requirements.

Legal category POM-V (previously POM). Packaging Quantities Boxes containing 20×150 g sachets, pots containing 2.5 kg. Further information Amoxicillin is a bactericidal antibiotic belonging to the semisynthetic penicillin group. It owes its activity to the inhibition of the development of the peptidoglycan network structure in the bacterial cell wall. Amoxicillin is a semisynthetic penicillin with a broad spectrum of activity against Gram positive and Gram negative bacteria. Amoxicillin is well absorbed following oral administration and it is stable in the presence of gastric acids. Excretion of amoxicillin is mainly in the unchanged form via the kidneys to give high concentration in renal tissue and urine. Amoxicillin is well distributed in body fluids. Studies in birds have indicated that amoxicillin is distributed and eliminated more rapidly than in mammals. Biotransformation appeared a more important route of elimination in birds than in mammals. Marketing authorisation number VM 08007/4019.