Advocin 180 mg/ml Solution for Injection for Cattle

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Advocin 180 mg/ml Solution for Injection for Cattle


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Item Number: ADVOCIN1 
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50ml £99.49 Usually despatched within 24 hours
100ml £177.15 Usually despatched within 24 hours

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NB This is a prescription only medicine
How do I buy Prescription medicines from you?

  1. Obtain a Prescription from your vet
  2. Place your order online or by phone
  3. Write the order number on the top of the prescription and post it to us.
  4. Choose your delivery method. Either Royal Mail Special Delivery which operates a next working day service, requiring a signature(Our recommended option). Or First class post which is free and is usually next working day but may take longer.
  5. Hyperdrug Pharmaceuticals Ltd, Middleton In Teesdale, Barnard Castle, County Durham, DL12 0NG.

Can I send a faxed prescription or a photocopy?

No a prescription is a legal document which must be written according to UK regulations and signed and dated by a vet with UK registration. Photocopies or electronic copies are not valid.

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Description

Advocin 180 mg/ml Solution for Injection for Cattle.

Presentation

Advocin 180 solution is a clear sterile aqueous formulation of danofloxacin mesylate that contains 180 mg danofloxacin per ml. The product is ready for immediate administration.

Each ml contains 2.5 mg phenol and 5 mg monothioglycerol as preservative.

Uses

Advocin 180 contains danofloxacin, a fluoroquinolone antimicrobial agent that possesses potent in vitro activity against Mannheimia haemolytica, Pasteurella multocida, Histophilus somni and Escherichia coli, the bacterial pathogens most commonly associated with bovine respiratory disease, enteric disease and acute bovine mastitis.

Cattle and calves

Advocin 180 is specifically indicated for the treatment of bovine respiratory disease caused by Mannheimia haemolytica, Pasteurella multocida and Histophilus somni and for the treatment of acute bovine mastitis caused by Escherichia coli sensitive to danofloxacin.

Neonatal calves

Advocin 180 is also indicated for the treatment of enteric infections caused by Escherichia coli sensitive to danofloxacin.

Dosage and administration

6 mg/kg body weight (1 ml/30 kg body weight) as a single injection by the subcutaneous or intravenous route.

If clinical signs of respiratory or enteric disease persist 48 hours after the first injection, an additional dose at 6 mg/kg body weight may be administered. It is recommended to treat animals in the early stages of disease and to evaluate the response to treatment within 48 hours.

For the treatment of acute bovine mastitis, Advocin 180 should be administered at 6 mg/kg body weight (1 ml/30kg body weight) as a single injection by the subcutaneous or intravenous route. The clinical signs should be monitored carefully and supportive therapy should be given as appropriate. If clinical signs of acute bovine mastitis persist 36-48 hours after the first injection, the antibiotic treatment should be reviewed. It is recommended to treat animals in the early stages of disease and to evaluate the response to treatment within 36-48 hours.

For treatment of cattle weighing more than 450 kg, divide the subcutaneous dose so that no more than 15 ml are injected at one site. When dosing a large number of animals from a single vial, the use of an automatic syringe is recommended to avoid excessive broaching of the rubber stopper.

Contra-indications, warnings, etc

Cattle must not be slaughtered for human consumption during treatment. Cattle may be slaughtered for human consumption only after 8 days from the last treatment.

Milk for human consumption must not be taken during treatment. Milk for human consumption may only be taken from 4 days (96 hours) after the last treatment; i.e. at the eighth milking for cows milked twice daily.

Use of the product deviating from the instructions given above may increase the prevalence of bacteria resistant to fluoroquinolones and may decrease the effectiveness of treatment with other quinolones due to the potential for cross resistance.

For fluoroquinolones as a class, over-dosage at multiples of the recommended dose has been shown to induce erosion of articular cartilage. Care should be taken to dose accurately and Advocin 180 should be used with caution in animals with joint disease or cartilage growth disorders.

Subcutaneous injection of the product induces a moderate inflammatory response in the tissue around the injection site. The resultant lesions may persist for up to 30 days. At doses of three times the therapeutic dose (18 mg/kg bw), erythema of the nasal and ocular mucosae was induced and food intake was reduced.

Studies in laboratory animals have shown adverse effects on reproduction. At high doses in rats (100 to 200 mg/kg/day), increase in foetal delayed ossification and in dilation of the cerebral ventricles were observed. Dams given high doses produced fewer live pups per litter and pup weight and survival were adversely affected. The safety of the product has not been assessed in pregnant cows. The use of the product is not recommended for cows during pregnancy. The safety of the product has not been assessed in breeding bulls.

Persons with known hypersensitivity to quinolones should avoid any contact with the product.

Wash hands after use. In case of contact with the skin, wash off any product immediately with soap and water. If accidental eye exposure occurs, flush the eyes immediately with clean water.

Do not eat, drink or smoke during application.

Pharmaceutical precautions

Store in the original packaging.

Do not freeze.

Use the product within 28 days of withdrawal of the first dose from the bottle. Any unused product or waste material should be disposed of in accordance with national requirements.

Keep out of the sight and reach of children.

For animal treatment only.

Legal category

POM-V

Packaging quantities

Multidose glass vials containing 50 ml or 100 ml. Not all pack sizes may be marketed.

 

Delivery

Free shipping from Hyperdrug

Value Weight Delivery Charge*  
Over £49.00 Any Weight FREE*
Under £49.00 Under 250g £2.49
Under £49.00 No weight limit £4.99

Most orders are despatched the same day and standard delivery is 3 to 5 working days from despatch. FAST Expedited delivery options are available.

Estimated " Usually shipped in" information is shown against most products

 

Due to the large volume of parcels Royal Mail and Parcel Force handle over the Christmas period, we advise you give as much time as possible to receive your goods. Please ensure you order any essentials, such as prescription only medicines and diets, as soon as possible for UK delivery before Christmas. 
 
Last posting dates to expect goods before Christmas
Royal Mail - Wednesday 14th December
Parcel Force - Friday 16th December
Fast Track - Wednesday 21st December
 
Hyperdrug.co.uk website is open 24 hours a day, 7 days a week.
 
Office Opening hours 
Monday 19th - Friday 23rd - OPEN 8am - 5.30pm
Saturday 24th - Tuesday 27th - CLOSED
Wednesday 28th - Friday 30th - OPEN 8am - 5.30pm
Saturday 31st - Monday 2nd - CLOSED
Tuesday 3rd - Friday 6th - OPEN 8am - 5.30pm
Saturday 7th - OPEN 9am - 4pm

Overseas orders

Postage outside of the UK is from £4.95

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*Free delivery and selected charges on orders over £49.00 mainland UK Parcelforce Zone1 for more information check the delivery info page.
 
 

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