Advantix Spot On Solution for flea & tick treatment in dogs-Hyperdrug

Advantix Spot On Solution for dogs for the treatment and prevention of flea Ctenocephalides canis, Ctenocephalides felis infestations in dogs, repels sandfly, ticks and mosquitos in dogs. Fleas on dogs are killed within one day following treatment. One treatment prevents further flea infestation for four weeks. The product can be used as part of a treatment strategy for flea allergy dermatitis (FAD). The product has a persistent acaricidal and repellent effect for four weeks (Rhipicephalus sanguineus, Ixodes ricinus) or three weeks (Dermacentor reticulatus), respectively, against tick infestations. One treatment provides repellent (anti-feeding) activity against sand flies (Phlebotomus papatasi) for two weeks and against mosquitoes for two (Aedes aegypti) or four (Culex pipiens) weeks, respectively.

A clear yellowish to brownish, non-aqueous solution containing imidacloprid and permethrin. The product is presented in a single use plastic tube for dermal (spot-on) treatment in dogs. Each tube contains 0.4ml (40 mg imidacloprid, 200 mg permethrin), 1.0 ml (100 mg imidacloprid, 500 mg permethrin), 2.5 ml (250 mg imidacloprid, 1250 mg permethrin) and 4 ml (400 mg imidacloprid, 2000 mg permethrin) respectively, as listed above. The product also contains 0.1% w/v butylated hydroxytoluene (Ph Eur) as a preservative Uses For the treatment and prevention of flea (Ctenocephalides canis, Ctenocephalides felis) infestations in dogs only. Fleas on dogs are killed within one day following treatment. One treatment prevents further flea infestation for four weeks. The product can be used as part of a treatment strategy for flea allergy dermatitis (FAD). The product has a persistent acaricidal and repellent effect for four weeks (Rhipicephalus sanguineus, Ixodes ricinus) or three weeks (Dermacentor reticulatus), respectively, against tick infestations. One treatment provides repellent (anti-feeding) activity against sand flies (Phlebotomus papatasi) for two weeks and against mosquitoes for two (Aedes aegypti) or four (Culex pipiens) weeks, respectively.

Dosage and administration Please refer to Table 1.

The recommended minimum dose is: 10 mg/kg bodyweight (bw) imidacloprid and 50 mg/kg bw permethrin. To reduce re-infestation from emergence of new fleas it is recommended that all dogs in a household be treated. Other pet animals living in the same household should also be treated with a suitable product. To further aid in reducing environmental challenge, the additional use of a suitable environmental treatment against adult fleas and their developmental stages is recommended. The product remains effective if the animal becomes wet. However, prolonged, intense exposure to water should be avoided. In cases of frequent water exposure the duration of activity may be reduced. In these cases do not re-treat more frequently than once weekly. If the dog requires shampooing, it is better to do so before applying Advantix or at least two weeks after application so as to ensure satisfactory efficacy of the product. Refer to the dosage table. Method of Administration For dermal use only. Remove one pipette from the package. Hold pipette in an upright position, twist and pull cap off. Turn the cap around and place the other end of the cap back on the pipette. Twist cap to break seal, then remove cap from pipette.

The dog should be standing for easy application. Apply only to undamaged skin. Administration to dogs weighing under 10 kg Part the coat between the shoulder blades until the skin is visible. Place the tip of the pipette on the skin and squeeze firmly several times to empty the contents directly onto the skin.

Administration to dogs weighing 10 kg and over The entire contents of the Advantix® pipette(s) should be applied evenly to four spots on the midline of the back from the shoulder to the base of the tail. At each spot, part the hair until the skin is visible. Place the tip of the pipette on the skin and gently squeeze to expel a portion of the solution onto the skin. Do not apply an excessive amount of solution at any one spot that could cause some of the solution to run off the side of the dog.

Use during pregnancy and lactation The product may be used during pregnancy and lactation.

Contra-indications, warnings, etc Do not use on cats.

This product is extremely poisonous to cats and could be fatal due to the unique physiology of this species which is unable to metabolise certain compounds, including permethrin. To prevent cats from being accidentally exposed to the product, keep cats away from treated dogs until the application site is dry. It is important to ensure that cats do not groom the site of application on a dog which has been treated with this product. Seek veterinary advice immediately if this occurs. In the absence of available data, the product should not be used on puppies of less than 7 weeks of age. Each product also has a minimum weight limit :

Do not use in cases of known hypersensitivity to the active substances. Care should be taken to avoid the contents of the pipette coming into contact with the eyes or mouth of the recipient dog. Care should be taken to administer the product correctly as described above, under Method of Administration. In particular, oral uptake due to the licking of the application site by treated or in-contact animals should be avoided. Consult your veterinary surgeon before using the product on sick and debilitated dogs. On rare occasions, reactions in dogs may include transient skin sensitivity (including increased pruritus, alopecia and erythema at the application site) or lethargy. Poisoning following inadvertent oral uptake in dogs is unlikely but may occur in very rare cases. In this event, neurological signs such as tremor and lethargy can occur. Treatment should be symptomatic under veterinary medical attention. There is no known specific antidote. User Safety: Avoid contact between the product and skin, eyes or mouth. Do not eat, drink or smoke during application. Wash hands thoroughly after use. In case of accidental spillage on human skin, wash off immediately with soap and water. People with known skin sensitivity may be particularly sensitive to this product. If the product gets accidentally into the eyes, they should be thoroughly flushed with water. If skin or eye irritation persists, or if the product is accidentally swallowed, obtain medical attention immediately and show the package insert to the physician. Treated dogs should not be handled, especially by children, until the application site is dry. This may be ensured by treating dogs when children are not present, eg in the evening after children have gone to bed. In this case, recently treated dogs should not be allowed to sleep together with their owner, especially children. Environmental Safety: After use, replace cap on tube. Any unused product or waste material should be disposed of in accordance with national requirements. Advantix® Spot-on should not be allowed to enter water courses as this may be dangerous for fish and aquatic organisms. The product is dangerous to aquatic organisms. Do not, under any circumstances, allow treated dogs to enter any type of surface water, such as ponds, for at least 48 hours after treatment. Permethrin containing products are toxic to honey bees. Pharmaceutical precautions Do not freeze. After opening the foil pouch do not store above 30°C. All pipettes should be used within 18 months after opening the foil pouch or before expiry date on the pipette, whichever is the earlier.

Legal category POM-V (previously POM) Packaging Quantities Heat-sealed blister packs containing 4 unit dose pipettes in a sealed aluminium pouch, packed with an instruction sheet into a cardboard box. Further information Imidacloprid is effective against both adult and larval flea stages. Larvicidal flea efficacy in the surroundings of the treated pet has also been demonstrated. Larval stages in the dog’s immediate surroundings are killed following contact with a treated animal. Permethrin belongs to the type I class of pyrethroid acaricides and insecticides and also acts as a repellent. The combination is synergistic. As an activator of arthropod ganglia, imidacloprid increases the efficacy of permethrin. Ticks already on the dog may not be killed within the two days following treatment and may remain attached and visible. Therefore the removal of ticks already on the dog at the time of treatment is recommended, in order to prevent them from attaching and having a blood meal. The product provides repellent (anti-feeding) activity against ticks, sand flies and mosquitoes. Preventing parasites from taking a blood meal reduces the risk of disease transmission (e.g. Borreliosis, Rickettsiosis, Ehrlichiosis, Leishmaniasis). However, there may be an attachment of single ticks or bites by single sand flies or mosquitoes. For this reason, a transmission of infectious diseases by these parasites cannot be completely excluded if conditions are unfavourable. There is no known interaction with other medicaments or other forms of interaction. No adverse clinical signs were noted in healthy puppies and adult dogs exposed to 5 x overdosage, and for puppies whose mothers were treated with 3 x overdosage of the product. The product is indicated for dermal administration. Following topical application in dogs, the solution rapidly distributes over the body surface of the animal. Both active substances remain detectable on the skin and hair of the treated animal for 4 weeks. Acute dermal studies in the rat and target animal, overdose and serum kinetic studies have established that systemic absorption of both active substances after application on intact skin is low, transient and not relevant for the clinical efficacy. The solvent in Advantix® Spot-on may stain certain materials including leather, fabrics, plastics and finished surfaces. Allow the application site to dry before permitting contact with such materials. Marketing authorisation number