Activyl Spot-on Solution for Cats 200mg (pack of 4)

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Activyl Spot-on Solution for Cats 200mg (pack of 4)


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Item Number: ACTIVYLCAT 
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Unit Price:

£15.69 (Incl. Vat)

Usually despatched within 24 hours

Quantity

NB This is a prescription only medicine
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  5. Hyperdrug Pharmaceuticals Ltd, Middleton In Teesdale, Barnard Castle, County Durham, DL12 0NG.

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No a prescription is a legal document which must be written according to UK regulations and signed and dated by a vet with UK registration. Photocopies or electronic copies are not valid.

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Description

Unit dose (ml)

Indoxacarb (mg)

 

Activyl spot-on solution for very small dogs

0.51

99.45

Activyl spot-on solution for small dogs

0.77

150.15

Activyl spot-on solution for medium dogs

1.54

300.30

Activyl spot-on solution for large dogs

3.08

600.60

Activyl spot-on solution for extra large dogs

4.62

900.90

Activyl spot-on solution for small cats

0.51

99.45

Activyl spot-on solution for large cats

1.03

200.85

Excipients: Isopropyl alcohol 354 mg/ml.

 

 

For a full list of excipients, see Section "Pharmaceutical Particulars".

Pharmaceutical form

Spot-on solution. A clear, colourless to yellow solution.

Clinical particulars

Target species

Dogs and cats

Indications for use

For dogs and cats: Treatment and prevention of flea infestation (Ctenocephalides felis).The veterinary medicinal product can be used as part of a treatment strategy for flea allergy dermatitis (FAD). Developing stages of fleas in the pet’s immediate surroundings are killed following contact with Activyl treated pets.

Contra-indications

None.

Special warnings for each target species

The safety of Activyl has not been established in dogs and cats younger than 8 weeks of age.

The safety of Activyl has not been established in dogs weighing less than 1.5 kg and in cats weighing less than 0.6 kg.

Special precautions for use

Care should be taken to apply the dose to an area where the animal cannot lick it off, as described under Amounts to be administered and administration route, and to ensure that animals do not groom each other immediately following treatment. Care should be taken to ensure that the content of the pipette or the applied dose does not come into contact with the eyes of the recipient and/or other animals. The product remains effective following shampoo treatment, water immersion (swimming, bathing) and exposure to sunlight. However, animals should not be allowed to swim or treated with shampoo within 48 hours after treatment.

User warnings:

Do not eat, drink or smoke while handling the veterinary medicinal product. The sachet is child-resistant. Keep the product in the sachet until use, in order to prevent children from getting direct access to the product. Keep the used pipette out of reach and sight of children. Wash hands immediately after use. This product contains indoxacarb. People with known hypersensitivity to indoxacarb should not use this product. As the veterinary medicinal product may cause moderate eye irritation, avoid contact with eyes. If this occurs, rinse slowly and gently with water. This product is highly flammable. Keep away from heat, sparks, open flame or other sources of ignition.

Adverse reactions

A brief period of hypersalivation may occasionally occur if the animal licks the application site immediately after treatment. This is not a sign of intoxication and disappears within some minutes without treatment. Correct application will minimise licking of the application site.Transitory scratching or hair loss at the application site may occur.These effects will usually resolve without treatment.

The application of the veterinary medicinal product may produce a local, temporary oily appearance or hair clumping at the application site. A dry white residue may be also observed. This is normal and will generally resolve within a couple of days after administration. These changes do not affect the safety or efficacy of the veterinary product.

Use during pregnancy, lactation or lay

Do not use in pregnant or lactating animals or in animals intended for breeding.

Interactions

None known.

Amounts to be administered and administration route

Dosage schedule:

Dogs: The recommended dose is 15 mg indoxacarb/kg bodyweight, equivalent to 0.077 ml/kg bodyweight. The following table defines the size of pipette to be used according to the weight of the dog:

Weight of Dog (kg)

Pipette size to be used

Volume (ml)

Indoxacarb (mg/kg)

< 6.5

Activyl Spot-on-Solution for very small dogs

0.51

Min. of 15

6.6 - 10

Activyl Spot-on solution for small dogs

0.77

15-23

10.1 - 20

Activyl Spot-on solution for medium dogs

1.54

15-30

20.1 - 40

Activyl Spot-on solution for large dogs

3.08

15-30

40.1 - 60

Activyl Spot-on solution for very large dogs

4.62

15-23

> 60 kg

The appropriate combination of pipettes should be used.

 

 

 

 

 

 

Cats: The recommended dose is 25 mg indoxacarb/kg bodyweight, equivalent to 0.128 ml/kg bodyweight. The following table defines the size of pipette to be used according to the weight of the cat:

Weight of Cat (kg)

Pipette size to be used

Volume (ml)

Indoxacarb (mg/kg)

= 4

Activyl Spot-on solution for small cats

0.51

Minimum of 25

> 4

Activyl Spot-on solution for large cats

1.03

Maximum of 50

Method of administration: For spot-on use only. Open one sachet and remove the pipette.

Step 1: The animal should be standing for easy application. With one hand, hold pipette in an upright position away from your face and with the other hand, snap tip open by bending it and folding it back on itself.

Step 1

Activyl figure 1 (MSD)

Step 2: Part the hair until the skin is visible and place pipette tip against the skin between the shoulder blades for dogs, or at the base of the skull for cats. Squeeze pipette firmly applying the entire contents directly to the skin.

Step 2

Activyl figure 2 (MSD)

In larger dogs, the entire contents of the pipette(s) should be applied evenly to two or three or four spots, all located at different application sites along the backline from the shoulder to the base of the tail. Do not apply an excessive amount of solution at any one spot which could cause some of the solution to run off the side of the animal.

Step 3

Activyl figure 3 (MSD)

Treatment schedule: Following a single administration, the veterinary medicinal product will prevent further flea infestation for at least 4 weeks.

Overdose

No adverse effects were observed in dogs and cats aged 8 weeks or older administered 5 times the recommended dose on 8 occasions at 4 weeks intervals or administered 5 times the recommended dose on 6 occasions at 2 weeks intervals.

Withdrawal periods

Not applicable.

Pharmacological particulars

Pharmacodynamic properties

ATC Vet Code QP53AX27

Pharmacotherapeutic group Pharmacotherapeutic group: Ectoparasiticides for topical use.

Indoxacarb is an ectoparasiticide belonging to the oxadiazine chemical family. After being converted into a metabolite, indoxacarb is active against adult, larval and egg stages of insects. In fleas, in addition to its adulticidal activity, indoxacarb activity on the developing larval stages in the immediate surroundings of the treated pet has been demonstrated. Indoxacarb is a pro-drug that requires bioactivation by the insect enzymes to exert its pharmacodynamic effects. It enters the insect primarily through ingestion but is also absorbed, to a lesser degree, through the insect cuticle. In the mid-gut of susceptible insect species, the insect’s enzymes remove the carbomethoxy group from parent indoxacarb, and convert it into its biologically active form.The bioactivated metabolite acts as a voltage-dependent sodium channel antagonist in insects, by blocking the sodium channels that regulate the flow of sodium ions in the insect’s nervous system. This results in a rapid cessation of feeding within 0 to 4 hours after treatment followed by cessation of egg laying (oviposition), paralysis and death occurring within 4 to 48 hours.

Pharmacokinetic properties

Following a single spot-on application of the product, indoxacarb can still be detected in both skin and hair coat after 4 weeks post-treatment. Absorption through the skin also occurs, but this systemic absorption is partial and not relevant for the clinical efficacy. The absorbed indoxacarb is extensively metabolised by the liver to a variety of metabolites. The major route of excretion is in faeces.

Pharmaceutical particulars

Excipients

Triacetin, Ethyl acetoacetate and Isopropyl alcohol.

Major incompatibilities

None known.

Shelf life

Shelf-life of the veterinary medicinal product as packaged for sale: 3 years.

Special precautions for storage

This veterinary medicinal product does not require any special temperature storage conditions. Store in the original package, in order to protect from moisture.

Immediate packaging

Cardboard box of 1 or 4 spot-on applicators, consisting of 0.51, 0.77, 1.03, 1.54, 3.08 and 4.62 ml pipettes. One size only per box. The pipette consists of a blister film (polypropylene/cyclic-olefin-copolymer/polypropylene) and a foil lidstock (aluminium/polypropylene co-extruded) sealed into aluminium sachets. Not all pack sizes may be marketed.

Not all pack sizes may be marketed.

Disposal

Any unused veterinary medicinal product or waste materials derived from such veterinary medicinal products should be disposed of in accordance with local requirements. Activyl should not be allowed to enter surface waters as indoxacarb may have harmful effects on aquatic organisms.

Marketing Authorisation Holder (if different from distributor)

Intervet International BV, Wim de Körverstraat 35 , 5831 AN Boxmeer, The Netherlands.

Marketing authorisation number

Activyl 100 mg spot-on solution for very small dogs

EU/2/10/118/002

Activyl 100 mg spot-on solution for small dogs

EU/2/10/118/004

Activyl 100 mg spot-on solution for medium dogs

EU/2/10/118/006

Activyl 100 mg spot-on solution for large dogs

EU/2/10/118/008

Activyl 100 mg spot-on solution for extra large dogs

EU/2/10/118/010

Activyl 100 mg spot-on solution for small cats

EU/2/10/118/012

Activyl 100 mg spot-on solution for large cats

EU/2/10/118/014

 

 

Date of the first authorisation or date of renewal

18 February 2011.

Date of revision of the text

March 2012.

Any other information

Nil

Legal category

POM-V

Significant Changes

Delivery

Free shipping from Hyperdrug

Value Weight Delivery Charge*  
Over £49.00 Any Weight FREE*
Under £49.00 Under 250g £2.49
Under £49.00 No weight limit £4.99

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